Anticancer activities of genistein-topotecan combination in prostate cancer cells.

Prostate cancer is one of the leading causes of death in men aged 40 to 55. Genistein isoflavone (4', 5', 7-trihydroxyisoflavone) is a dietary phytochemical with demonstrated anti-tumour activities in a variety of cancers. Topotecan Hydrochloride (Hycamtin) is an FDA-approved chemotherapy drug, primarily used for secondary treatment of ovarian, cervical and small cell lung cancers.

Narratives of patients with skull base tumors and their family members: lessons for nursing practice.

The meaning of the experience of being told you or a family member have/has a serious brain tumor was revealed during a descriptive research study conducted to determine preoperative education needs. Eighteen patients and 15 family members participated immediately following the office visit with the neurosurgeon and/or on admission to hospital, for a total of 29 interviews and 13 questionnaires. Twenty-four interviews were conducted with 13 patients and 11 family members in the pre-discharge phase of the research.

Education and information needs identified by patients and key family members prior to surgery for a skull base neoplasm: implications for practice.

Many patients with extensive skull base neoplasms poorly understand the nature of their problems. Therefore, education of patients and family members is an important component of care. Research has established the benefits of pre-operative education for other types of surgery and information seeking as an important method of coping.