Publications by authors named "M B Chancellor"
This study aimed to improve machine learning models for diagnosing interstitial cystitis/bladder pain syndrome (IC/BPS) by comparing classical machine learning methods with newer AutoML approaches, utilizing biomarker data and patient-reported outcomes as features. We applied various machine learning techniques to biomarker data from the previous IP4IC and ICRS studies to predict the presence of IC/BPS, a disorder impacting the urinary bladder. Data were sourced from two nationwide, crowd-sourced collections of urine samples involving 2009 participants.
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- - Oral lichen planus (OLP) is a chronic inflammatory autoimmune condition affecting the mouth, often leading to decreased quality of life and potential cancer risks; traditional treatment primarily involves topical corticosteroids, which have undesirable side effects.
- - Interest is growing in alternative treatments, particularly topical calcineurin inhibitors (TCIs) like tacrolimus, which provide a steroid-sparing option and aim for localized effectiveness with less systemic absorption.
- - The management of OLP is complex and requires various treatment strategies; ongoing research is focused on developing safer, more effective therapies, including innovative drug delivery systems and biologics, to improve patient outcomes.
Iltamiocel Autologous Cell Therapy for the Treatment of Female Stress Urinary Incontinence: A Double-Blind, Randomized, Stratified, Placebo-Controlled Trial.
Melissa R Kaufman Howard B Goldman Christopher J Chermansky Roger Dmochowski Michael J Kennelly Michael B Chancellor
Neurourol Urodyn
November 2024
Article Synopsis
- - The study evaluated the safety and effectiveness of iltamiocel, an autologous muscle cell therapy, for treating stress urinary incontinence (SUI) in women, comparing it to a placebo group.
- - Results showed no significant difference in the overall reduction of stress incontinence episodes between groups, but iltamiocel was more effective in women with previous SUI surgeries, indicating potential benefits for this specific population.
- - While the primary endpoint was not achieved, iltamiocel therapy was deemed safe, suggesting further research is needed for women with prior SUI surgery who lack effective treatment options.