Publications by authors named "M B Bhongade"
Frailty and sarcopenia are frequently observed in patients with end-stage liver disease. Frailty is a complex condition that arises from deteriorations across various physiological systems, including the musculoskeletal, cardiovascular, and immune systems, resulting in a reduced ability of the body to withstand stressors. This condition is associated with declined resilience and increased vulnerability to negative outcomes, including disability, hospitalization, and mortality.
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- Recent research highlights follicle-stimulating hormone (FSH) as a target for treating diseases like osteoporosis, obesity, and Alzheimer's, with findings showing that blocking FSH can prevent various health issues in mice.
- The development of a humanized FSH-blocking antibody called MS-Hu6 has shown promise in preventing osteoporosis in mice and has safe initial testing in monkeys, demonstrating effective localization to bone and bone marrow.
- MS-Hu6 has been optimized for stability and safety, showing no immunogenic responses in human cell cultures, making it ready for potential future human clinical trials.
Background: This study was carried out to evaluate and compare the levels of IL-35 in gingival crevicular fluid (GCF) in periodontally healthy subjects, patients with gingivitis and chronic periodontitis and to assess IL-35 as a marker for identification of periodontal disease activity.
Methods: GCF samples were obtained from periodontally healthy subjects (N.=15), gingivitis patients (N.
Aim: To evaluate effectiveness of demineralized freeze-dried bone allograft (DFDBA) block fixed by titanium screw for reconstructing interimplant papilla in maxillary esthetic zone during one-stage early loading multiple implant procedure.
Materials And Methods: A total of 20 implants were placed in 10 systemically healthy patients (2 implants per patient) for replacement of multiple teeth by early loading one-stage implants along with interimplant papilla reconstruction using DFDBA block fixed by titanium screw. At the baseline, 6 months, and at 1 year, clinical measurements (interimplant papillary height measurement, papilla contour) and radiographic measurements were recorded.
Context: Rehabilitation of jaws with reduced bone height is technically demanding and expensive. Short implants are emerging as an alternate in such cases.
Aim: This study aimed to evaluate the survival of implants of 8 mm in length (short implants), clinically and radiographically, in posterior resorbed ridges.