Publications by authors named "M B Bharathi"
The study synthesized Pluronic F-127 coated zinc oxide nanoparticles (PF-127ZnO NPs) using leaf extract and evaluated their antibacterial, antioxidant, and anticancer properties using various characterization methods such as UV-Vis, Fourier Transform Infra-Red, Photoluminescence spectroscopy, FESEM, EDAX, TEM, SAED, XRD, and DLS. The disc diffusion technique was used to evaluate the antibacterial properties of synthesized Pluronic F-127 coated zinc oxide nanoparticles against various pathogens and significant anticancer activity was noticed. The study examined the cytotoxicity of PF127ZnO nanoparticles to Hep3B cells .
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- Researchers created SiC nanoparticles coated with graphene oxide through femtosecond laser ablation in water, revealing unique structural features and silicene sheet micro-nanostructures in the solution.
- * The surfaces of the SiC showed high spatial frequency laser-induced periodic surface structures (LIPSS) with size variations linked to the resistivity of the SiC materials used.
- * The study explored the properties of annealed Au-deposited LIPSS for sensing applications, finding that rapid thermal annealing significantly enhanced surface-based detection of explosives like Tetryl through surface-enhanced Raman scattering (SERS).*
The challenge with breast cancer is its ongoing high prevalence and difficulties in early detection and access to effective care. A solution lies in creating tailored metal-organic frameworks to encapsulate anticancer drugs, enabling precise and targeted treatment with less adverse effects and improved effectiveness. Zeolitic imidazolate framework-8 (ZIF-8) and carboplatin (CP)-loaded ZIF-8 were synthesized and characterized using various analytical techniques.
View Article and Find Full Text PDFInnovative drug delivery platforms for selective, regulated, and sustained release of anticancer drugs are crucial in cancer treatment. This study presents nanoparticles developed from chitosan (CS), graphene oxide (GO), and magnetite (FeO), and their nanocomposites to enhance the loading and release efficiency of camptothecin (CPT). Nanostructures were characterized using imaging microscopy, FT-IR, and X-ray diffraction, with an average crystallite size of 5.
View Article and Find Full Text PDFScreening miRNAs to Hinder the Tumorigenesis of Renal Clear Cell Carcinoma Associated with KDR Expression.
Curr Cancer Drug Targets
September 2024
Article Synopsis
- The study investigates the role of Kinase Insert Domain Receptor (KDR) and its associated microRNAs (miRNAs) in renal cell carcinoma, highlighting the potential importance of their findings for future research.
- Utilizing various databases and tools, the researchers identified how miRNAs regulate KDR expression and validated their results with patient samples.
- Results showed that KDR expression was significantly elevated in tumor tissues compared to normal tissues, with miR-200c-3p being notably down-regulated, suggesting that higher levels of this miRNA could reduce KDR expression and potentially inhibit cancer progression.