Publications by authors named "M B Barrault"
is a major contributor to bacterial-associated mortality, owing to its exceptional adaptability across diverse environments. Iron is vital to most organisms but can be toxic in excess. To manage its intracellular iron, , like many pathogens, employs intricate systems.
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- Pathogenic bacteria like Staphylococcus aureus use regulatory RNA (sRNA) called IsrR to adapt to low iron conditions and maintain virulence.
- IsrR helps conserve iron by down-regulating genes for iron-containing enzymes, particularly affecting the tricarboxylic acid (TCA) cycle and the enzyme aconitase.
- Aconitase also acts as a regulatory protein that influences its own expression and modulates the expression of other enzymes, thereby helping the bacteria cope with iron scarcity.
The tension on the supply of surgical and FFP2 masks during the first wave of the COVID-19 pandemic leads to study the potential reuse of these masks. As washing is easily adaptable at home, this treatment solution was retained. In this work, thirty-six references of surgical masks and four FFP2 masks were tested without being worn or washed and after several washing cycles.
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- Staphylococcus aureus, an opportunistic pathogen, adjusts its metabolism to survive during iron scarcity in the host.
- A small non-coding RNA called IsrR is crucial for this adaptation, as it represses the translation of mRNAs for iron-dependent enzymes under iron-starved conditions.
- IsrR enhances bacterial survival and lethality in infections, highlighting its significant role in the iron-sparing response and demonstrating the evolutionary advantages of RNA-based regulation in bacteria.
Mediator is a conserved coregulator playing a key role in RNA polymerase (Pol) II transcription. Mediator also links transcription and nucleotide excision repair (NER) via a direct contact with Rad2/ERCC5(XPG) endonuclease. In this work, we analyzed the genome-wide distribution of Rad26/ERCC6(CSB) and Rad1-Rad10/ERCC4(XPF)-ERCC1, addressing the question of a potential link of these proteins with Mediator and Pol II in yeast Our genomic analyses reveal that Rad1-Rad10 and Rad26 are present on the yeast genome in the absence of genotoxic stress, especially at highly transcribed regions, with Rad26 binding strongly correlating with that of Pol II.
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