Appraisal of the Neuroprotective Potentials of Isoeugenol Using and Approaches.

Background: Alzheimer's disease (AD) is a neurodegenerative condition that affects the elder population and is linked to behavioral instability and cognitive decline. Only a few drugs are approved for clinical management of AD. Volatile oils and their components exhibit diverse pharmacological potentials, including neuroprotective properties.

Integrating fractional-order SEI1I2I3QCR model with awareness and non-pharmaceutical interventions for optimal COVID-19 pandemic.

Infectious diseases like COVID-19 continue to pose critical challenges globally, underscoring the need for effective control strategies that go beyond traditional vaccinations and treatments. This study introduces an advanced SEI1I2I3QCR model, uniquely incorporating fractional-order delay differential equations to account for latency periods and dynamic transmission patterns of COVID-19, improving accuracy in capturing disease progression and peak oscillations. Stability analyses of the model reveal the critical role of delay and fractional order parameters in managing disease dynamics.

Benzothiazole Derived Ether Hybrids as Potent Anti-Thymidine Phosphorylase Agents: Synthesis, In Vitro, and Computational Investigations.

This work is based on the synthesis of new ether derivatives bearing benzothiazole (BTA) scaffold through multistep reaction process. Initially, BTA was prepared by refluxing 4-hydroxybenzaldehyde with aminothiophenol having sodium metabisulfite in dimethylformamide (DMF); subsequently, the product was further refluxed with different substituted benzyl and alkyl bromides in acetone to get ether hybrids of BTA in good yields. Structurally, these compounds were confirmed by means of H, C-NMR, and mass spectrometry and evaluated for in vitro thymidine phosphorylase (TP) inhibitory activity.

Impact of synthetic insecticides on the life table parameters of Trichogramma chilonis under laboratory conditions.

Trichogramma chilonis (Ishii) is an important egg parasitoid of Helicoverpa species in tomato growing areas of Pakistan. Different insecticides are used for the management of H. armigera, but these insecticides have significantly reduced the effectiveness of T.