Publications by authors named "M Azria"
Article Synopsis
- * 5-HOB shows a high affinity for the human β-AR and effectively promotes muscle hypertrophy while exhibiting significantly lower cardiac activity compared to the well-known β-AR agonist, formoterol.
- * In preclinical tests on rats and monkeys, 5-HOB led to increased muscle weight without adversely affecting heart function, indicating its potential as a safer option for treating muscle-wasting conditions.
Unlabelled: In healthy postmenopausal women, nasal salmon calcitonin blunted distal radius and tibia bone microstructure degradation.
Introduction: Nasal salmon calcitonin (NSC) has been reported to lower vertebral fracture risk by 33%, but to modestly increase spine areal bone mineral density (aBMD) by 1.5%.
8-(N-2-hydroxy-5-chlorobenzoyl)-amino-caprylic acid (5-CNAC), a compound lacking pharmacological activity enhances the absorption of salmon calcitonin, when co-administered. Disposition and biotransformation of 5-CNAC was studied in six healthy postmenopausal women following a single oral dose of 200mg (14)C-radiolabeled 5-CNAC (as disodium monohydrate salt). Blood, plasma, urine and feces collected over 7 days were analyzed for radioactivity.
View Article and Find Full Text PDFParathyroid hormone (PTH), currently the only marketed anabolic treatment for osteoporosis, is available as the full-length hormone, human PTH1-84, or as the human PTH1-34 fragment (teriparatide). Both must be administered as a daily subcutaneous (sc) injection. A new oral formulation of human PTH1-34 (PTH134) is being developed as a more convenient option for patients.
View Article and Find Full Text PDFBackground: This short communication focuses the on articular cartilage and the subchondral bone, both of which play important roles in the development of osteoarthritis (OA). There are indications that estrogen-deficiency, as the post-menopausal state, accelerate the development of OA.
Findings: We investigated, which extracellular matrix (ECM) protein, proteases and different pro-inflammatory factors was up- or down-regulated in the knee joint tissue in response to estrogen-deficiency in rats induced by ovariectomy.