Temperature-stable high-power properties of (K,Na)NbO-based piezoelectric ceramics.

Piezoelectric ceramics tailored for high-power resonance applications are investigated, utilizing a composite structure comprising the ferroelectric phase (K,Na)NbO as a matrix integrated with the alkali titanoniobate dielectric phase KTiNbO. Achieving a mechanical quality factor of 750, comparable to lead-based counterparts, highlights their suitability for demanding applications. Crucially, these ceramics exhibit exceptional temperature stability of electromechanical properties, a critical attribute for real-world applications subject to temperature variations.

Initial Evaluation of lncRNA A2M-AS1 Gene Expression in Multiple Sclerosis Patients.

Background: Multiple sclerosis (MS) is one of the three leading neurodegenerative diseases worldwide. Gene expression profile studies play an important role in recognizing and preventing disease. Considering the inherent ability of biomarkers to diagnose and prognose the occurrence of a disease, with the aim of gene therapy and changing gene expression, it can be helped to treat it.

Best Practices for Development and Validation of Enzymatic Activity Assays to Support Drug Development for Inborn Errors of Metabolism and Biomarker Assessment.

Aberrant or dysfunctional cellular enzymes are responsible for a wide range of diseases including cancer, neurodegenerative conditions, and metabolic disorders. Deficiencies in enzyme level or biofunction may lead to intracellular accumulation of substrate to toxic levels and interfere with overall cellular function, ultimately leading to cell damage, disease, and death. Marketed therapeutic interventions for inherited monogenic enzyme deficiency disorders include enzyme replacement therapy and small molecule chaperones.