Publications by authors named "M Aversa"
In this paper, the authors describe an experimental study carried out on biological samples consisting of a 96-h mature Methicillin-Resistant-Staphylococcus-Aureus biofilm. The initial objective was to electrically characterize the biofilm using impedance spectroscopy, by scanning a wide range of frequencies [1 Hz ÷ 10 MHz]. Concurrently, confocal microscopy observations, XTT assays, crystal violet staining method and colony-forming unit assay were performed to characterize the biological activity.
View Article and Find Full Text PDFBackground: Autoantibodies and de novo donor HLA-specific antibodies (dnDSA) may contribute to chronic lung allograft dysfunction (CLAD). However, the breadth of reactivities against self-antigens and their association with CLAD has been underexamined. In a single-center study, we screened lung transplant (LTx) recipients for novel autoantibodies at transplant and 6 months post-LTx, assessed dnDSA exposure, and CLAD-free survival.
View Article and Find Full Text PDFObjective: To determine the impact of prolonged storage of donor lungs at 10 °C for up to 24 hours on outcome after lung transplantation.
Background: An increasing body of evidence suggests 10 °C as the optimal storage temperature for donor lungs. A recent study showed that cold ischemic times can be safely expanded to >12 hours when lungs are stored at 10 °C.
Article Synopsis
- Acute graft-versus-host disease (aGVHD) is a serious, rare complication that can occur after solid organ transplants, especially in organs with a lot of lymphoid tissue like the liver and intestines, and is becoming more relevant in lung transplants due to increasing numbers of procedures.
- The understanding of aGVHD’s causes, risk factors, and treatment strategies is limited, leading to potential delays in diagnosis and inferior patient outcomes, as there’s currently no standardized management approach.
- This report highlights a unique case of aGVHD that developed nearly a year post-lung transplant and was effectively treated with ruxolitinib, suggesting a potential new approach to managing this condition similar to treatments used for aGVHD
Background: This study aims to assess the activity of solutions containing povidone-iodine (PI) and hydrogen peroxide (HO) alone or combined on the biofilm of microbial species in the contest of periprosthetic joint infection (PJI).
Methods: Different antiseptic solutions were tested on 2-day-old biofilms of Gram-positive and Gram-negative bacteria and fungi at 1 and 3 minutes of exposure. The efficacy of these solutions was evaluated by measuring the biofilm metabolic activity by methoxynitrosulfophenyl-tetrazolium carboxanilide (XTT) reduction assay.