Identification and characterization of two novel KCNH2 mutations contributing to long QT syndrome.

We identified two different inherited mutations in KCNH2 gene, or human ether-a-go-go related gene (hERG), which are linked to Long QT Syndrome. The first mutation was in a 1-day-old infant, whereas the second was in a 14-year-old girl. The two KCNH2 mutations were transiently transfected into either human embryonic kidney (HEK) cells or human induced pluripotent stem-cell derived cardiomyocytes.

ELUCIDATING THE ROLE OF THE HIS-PURKINJE SYSTEM DURING LONG QT MEDIATED ARRHYTHMIAS.

Mutation in the hERG gene leading to partial or complete blockade of the rapid delayed rectifier current causes Long QT Type 2 (LQT2) phenotype, the second most common form of Long QT Syndrome. However, the exact involvement of the His-Purkinje System (HPS) remains elusive. We utilized a finite element model of the rabbit ventricles integrated with a HPS to elucidate the role of HPS during LQT2-mediated arrhythmia.

A comparison of intervertebral ligament properties utilized in a thoracic spine functional unit through kinematic evaluation.

Ligament properties in the literature are variable, yet scarce, but needed to calibrate computational models for spine clinical research applications. A comparison of ligament stiffness properties and their effect on the kinematic behavior of a thoracic functional spinal unit (FSU) is examined in this paper. Six unique ligament property sets were utilized within a volumetric T7-T8 finite element (FE) model developed using computer-aided design (CAD) spinal geometry.

Wearable Sensor Gait Analysis of Fall Detection using Attention Network.

The statistical data from the National Council on Aging indicates that a senior adult dies in the US from a fall every 19 minutes. The care of elderly people can be improved by enabling the detection of falling events, especially if it triggers the pneumatic actuation of a protective airbag. This work focuses on detecting impending fall risk of senior subjects within the geriatric population, towards a planned approach to mitigating fall injuries through pneumatic airbag deployment.