Identification of immune suppressor candidates utilizing comparative transcriptional profiling in histiocytic sarcoma.

Histiocytic sarcoma (HS) is a rare yet lethal malignancy with no established standard of care therapies. A lack of pre-clinical models limits our understanding of HS pathogenesis and identification of therapeutic targets. Canine HS shares multiple clinical and genetic similarities with human HS, supporting its use as a unique translational model.

Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma.

Background: Immune checkpoint inhibitors (ICIs) are becoming the standard of care for recurrent and metastatic cancer. Opioids, the primary treatment for cancer-related pain, are immunosuppressive raising concerns about their potential to interfere with the efficacy of ICIs. We hypothesize that exogenous opioids given for analgesia suppress antitumor immunity via T cell-mediated mu opioid receptor 1 (OPRM1) signaling.

Does Restoration of Lumbar and Segmental Cobb Angle Affect Fusion Outcome in Short-Segment Posterior Lumbar Fusion?

Objective: To study the effect of lumbar lordosis change and pelvic parameters on surgical outcomes such as fusion versus nonfusion (pseudarthrosis), adjacent segment pathology (ASP), and reoperation in patients undergoing 1-level, 2-level, and 3-level posterior lumbar fusion (PLF).

Methods: Adult patients with degenerative spine disease who had undergone PLF between L2 and L5 levels at an academic center between 2010 and 2020 were included. Preoperative and early postoperative lateral standing radiographs of the lumbar spine were used to measure preoperative lumbar Cobb angle, postoperative lumbar Cobb angle, preoperative segmental Cobb angle (measured from the superior end plate of the upper instrumented vertebra to the inferior end plate of the lower instrumented vertebra), postoperative segmental Cobb angle, preoperative pelvic incidence, and pelvic tilt.

Stakeholder perspectives following implementation of Vietnam's first speech-language pathology degrees: recommendations for future curriculum development.

Purpose: To investigate perspectives of multiple stakeholders involved in development and delivery of Vietnam's first speech-language pathology degrees and derive recommendations for future degrees in Vietnam and other Majority World countries.

Methods: An exploratory-descriptive qualitative research design using focus groups and individual semi-structured interviews in the preferred language (English or Vietnamese) was used, with 70 participants from five stakeholder groups: project managers, students, academic educators, placement supervisors and interpreters. Transcriptions were analysed using thematic network analysis.