Synergistic effects of AgNPs and zileuton on PCOS via ferroptosis and inflammation mitigation.

Background: The most prevalent endocrine disorder affecting women is PCOS. Programmed death of ovarian cells has yet to be elucidated. Ferroptosis is a kind of iron-dependent necrosis featured by significantly Fe-dependent lipid peroxidation.

Protective Effects of Kaempferol on Hepatic Apoptosis via miR-26a-5p Enhancement and Regulation of TLR4/NF-κB and PKCδ in a Rat Model of Non-Alcoholic Fatty Liver.

This study aimed to evaluate kaempferol's, a dietary flavonoid widely present in plants, potential impact on nonalcoholic fatty liver disease (NAFLD) and its underlying mechanisms. In this study, 60 adult male rats were used and divided into a control group receiving a standard pellet diet, a kaempferol-treated group receiving kaempferol (250 mg/kg), a high-fat diet (HFD) group receiving HFD, and a kaempferol-treated HFD group. At the end of the experiment, the total lipid profile and liver enzymes were assayed in the serum.

Aesthetic Outcome of Isolated Advancement Genioplasty With and Without Submental Liposuction in the Treatment of Skeletal Chin Deficiency in Double Chin Patients (A Randomized Controlled Clinical Trial).

This study was conducted to evaluate the effect of submental liposuction with advancement genioplasty versus advancement genioplasty alone on esthetics in double chin patients. Twenty-six patients with deficient chin were included in the study. The patients were distributed into 2 groups: submental fat liposuction in conjunction with advancement genioplasty group as intervention one and advancement genioplasty alone as a control group.

Effectiveness of sorafenib in treating intermediate-stage hepatocellular carcinoma patients refractory to transarterial chemoembolization.

Background: Switching to systemic therapy after transarterial chemoembolization (TACE) refractoriness is more inclined to preserve liver function and decrease disease progression. Hence, we conducted a comparison between the advantages of sorafenib therapy and the continuation of TACE in patients with intermediate-stage hepatocellular carcinoma (HCC) who developed TACE refractoriness.

Methods: This retrospective cohort work involved 1,200 patients with HCC who received TACE therapy at our institution between January 2018 and December 2022.

Eco-friendly impact of a novel green extract as a sustainable inhibitor to reduce acid corrosion of copper.

In this study, we deployed green extract (MOE) as a corrosion inhibitor for copper. The anticorrosion properties of MOE for Cu in 1 M HNO were investigated by various experimental and numerical techniques, including potentiodynamic polarization (PDP), electrochemical impedance spectroscopy (EIS), and a weight loss (WL) method at different temperatures. Additionally, scanning electron microscopy (SEM) coupled with energy-dispersive X-ray analysis (EDX) and atomic force microscopy (AFM) were utilized to examine the surface morphology of Cu with and without the extract.