Publications by authors named "M Atchison"
Article Synopsis
- During B-cell development, the pro-B-cell stage is crucial for committing to the B-cell lineage, and the transcription factor YY1 plays a key role in this process.
- Knocking out YY1 at the pro-B-cell stage stops B-cell development and enables these cells to convert into T lineage cells, demonstrating a shift in their genetic expression profiles.
- Research involving various sequencing techniques shows that the loss of YY1 not only affects B lineage commitment but also allows pro-B cells to exhibit flexibility in developing into multiple hematopoietic lineages due to changes in chromatin accessibility.
Women with severe mental illness and pregnancy suffer substantial travails in accessing care for mental and perinatal health. Women with psychotic illnesses such as schizophrenia face higher risks of pregnancy and postnatal complications. Similarly, lack of access to holistic psychiatric care presents particular perils for these women and their children.
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- The study investigates the epigenetic features of antigen receptor (AgR) genes in B and T cells, comparing them to embryonic stem (ES) cells and neurons.
- It finds that both B and T cell receptor loci show active histone modifications and transcription markers in lymphocytes, whereas these loci are largely inactive in neurons.
- The research suggests that the distinct epigenetic profiles in ES cells and lymphocytes could be related to the pluripotency of ES cells and the specific activation of lymphocytes at AgR loci.
Background: Skydiving is an increasingly popular recreational activity in the United States and worldwide. While it is considered a high-risk sport, the United States Parachute Association reported a fatality of .28 per 100 000 jumps in 2022.
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