Publications by authors named "M Assicot"

Objective: To evaluate the accuracy of procalcitonin (PCT) in predicting bacterial infection in ICU medical and surgical patients.

Setting: A 10-bed medical surgical unit.

Design: PCT, C-reactive protein (CRP), interleukin 6 (IL-6) dosages were sampled in four groups of patients: septic shock patients (SS group), shock without infection (NSS group), patients with systemic inflammatory response syndrome related to a proven bacterial infection (infect.

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Procalcitonin (PCT) has been described as an early and discriminating marker of bacteria-associated sepsis in patients. However, little is known of its source and actions, especially with regard to its relation to tumor necrosis factor (TNF). TNF is responsible for the release of several other mediators of sepsis e.

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Objectives: Procalcitonin (PCT) has been described as an early, discriminating marker of bacteria-associated sepsis in patients. However, little is known of its source and actions, in part because no appropriate animal models have been available. We tested the hypothesis that plasma PCT increases during various pathophysiological conditions, such as hemorrhagic shock and sepsis, which differ with regard to the degree of associated endotoxemia.

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Background: Principal component analysis (PCA) is a powerful mathematical method able to analyze data sets containing a large number of variables. To our knowledge, this method is applied here for the first time in the field of medical laboratory analysis.

Methods: PCA was used to evaluate the results of a blind comparative study of 21 carcinoembryonic antigen (CEA) reagent kits used to determine CEA concentration in a panel of sera from 80 patients.

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Synopsis of recent research by authors named "M Assicot"

  • - M Assicot's research primarily focuses on the use of biomarkers, particularly procalcitonin (PCT), in diagnosing and predicting outcomes related to bacterial infections and sepsis in critically ill patients.
  • - Key findings suggest that PCT levels can effectively differentiate between bacterial origins of acute circulatory failure and other conditions, highlighting its potential as a critical diagnostic tool in ICU settings.
  • - Additionally, Assicot's work explores the mechanisms behind PCT release, including its relationship with cytokines such as TNF, and emphasizes the importance of developing standardized methods for biomarker comparison in clinical studies.