Publications by authors named "M Asako"
Several studies suggest that hearing loss results in changes in the balance between inhibition and excitation in the inferior colliculus (IC). The IC is an integral nucleus within the auditory brainstem. The majority of ascending pathways from the lateral lemniscus (LL), superior olivary complex (SOC), and cochlear nucleus (CN) synapse in the IC before projecting to the thalamus and cortex.
View Article and Find Full Text PDFHistological analysis of glucocorticoid receptor and eosinophilic cytokines in the adenoid mucosal epithelium.
Int J Pediatr Otorhinolaryngol
September 2024
Article Synopsis
- Topical nasal steroids can shrink hypertrophic adenoids and alleviate related symptoms, but their exact mechanism is not fully understood, prompting this study.* -
- Histological analysis of adenoids and tonsils from 32 pediatric patients showed that adenoids had higher eosinophil infiltration and greater expression of glucocorticoid receptors and certain interleukins compared to tonsils.* -
- Findings suggest that inflammation in the adenoids, indicated by eosinophils and specific interleukin expressions, may contribute to adenoid hypertrophy, highlighting possible targets for treatment.*
Article Synopsis
- The MERIT study was a 52-week Phase III clinical trial that evaluated the efficacy and safety of mepolizumab for treating patients with chronic rhinosinusitis with nasal polyps (CRSwNP) in Japan, Russia, and China.
- Mepolizumab significantly improved nasal obstruction scores in patients compared to placebo, with some improvement seen in nasal polyp scores, and had a manageable safety profile with few serious adverse events.
- The findings suggest that mepolizumab is an effective treatment option for patients suffering from CRSwNP/ECRS in these regions.
This study reported two cases of acute life-threatening hemorrhage after Le Fort I osteotomy. In both cases, computed tomography and angiography revealed damage to the descending palatine artery, which was successfully treated by angiographic embolization. Although massive hemorrhage after Le Fort I osteotomy is rare, acute hemorrhage from the postoperative area may occur.
View Article and Find Full Text PDFEosinophilic airway inflammation, complicated by bronchial asthma and eosinophilic chronic rhinosinusitis (ECRS), is difficult to treat. The disease may become refractory when eosinophilic mucin associated with eosinophil peroxidase (EPX) and autoantibodies fills in the paranasal sinus and small airway. This study investigated the functional role of an anti-EPX antibody in eosinophilic mucin of ECRS in eosinophilic airway inflammation.
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