Publications by authors named "M Asagi"
Article Synopsis
- Two polysaccharides, ANP and AAP, were extracted from young buds of Acanthopanax sciadophylloides, with distinct sugar compositions and molecular weights (ANP: 1.07×10^4, AAP: 8.40×10^4).
- Both polysaccharides stimulated nitric oxide production and the expression of cytokine mRNAs in RAW264.7 cells, also activating NF-κB in RAW-Blue cells, indicating strong immunostimulatory properties.
- The effects were modulated through interactions with receptors TLR-4 and CD14, and ANP was also found to have anti-HSV-2 properties in vitro.
Distamycin A (Dst) is an antibiotic which binds to the minor groove of double-stranded DNA at A/T-rich regions. We have examined the affinity and mode of Dst binding to DNA duplexes containing a conserved A/T core and variable terminal A/T regions by using circular dichroism spectroscopy. The observed circular dichroism spectra were analyzed by singular value decomposition and fitted to a two-step binding model.
View Article and Find Full Text PDFBackground: Immune abnormalities are known to be involved in the pathogenesis of sporadic Parkinson disease.
Objective: To examine whether abnormalities in peripheral lymphocytes exist in Parkinson disease.
Methods: Immune mediators, including CD1a, CD3, CD4, CD8, CD45RO, and Fas (CD95), were examined in peripheral lymphocytes of patients by 3-color flow cytometry.
Heparin inhibited hemagglutination (HA) by pseudorabies virus (PRV), but not HA by Akabane virus, bovine adenovirus type 7, Fukuoka virus, Getah virus, Japanese encephalitis virus, and parainfluenza virus type 3 belonging to the families Bunyaviridae, Adenoviridae, Rhabdoviridae, Togaviridae, Flavivi-idae, and Paramyxoviridae, respectively. The minimal inhibitory concentration of heparin required to inhibit 8 HA U of PRV ranged from 0.005 to 0.
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