The effects of ANRIL polymorphisms on colorectal cancer, tumor stage, and tumor grade among Iranian population.

Background: Colorectal cancer (CRC) is a type of neoplasm, developing in the colon or rectum. The exact etiology of CRC is not well known, but the role of genetic, epigenetic, and environmental factors are established in its pathogenesis. Therefore, the aim of this research was to explore the effects of ANRIL polymorphisms on the CRC and its clinical findings.

Maternal and placental polymorphisms and preeclampsia susceptibility.

The possible effects of maternal and placental polymorphisms on preeclampsia were examined. The maternal blood of 315 preeclamptic and 317 control women and the placentas of 103 preeclamptic and 133 control women were enrolled in the study. polymorphisms were genotyped using a PCR-RFLP method.

Long non-coding RNA polymorphisms in papillary thyroid cancer and its severity.

: Long non-coding RNAs are likely to have a role in the pathogenesis of many diseases, including cancer. We hypothesised an effect of certain single nucleotide polymorphisms (SNPs) in papillary thyroid cancer. : Genomic SNPs in rs11333048, rs4977574, rs1333040 and rs10757274 were determined in 134 papillary thyroid cancer patients and 155 age- and sex-matched controls.

Effects of the MTOR and AKT1 genes polymorphisms on papillary thyroid cancer development.

Papillary thyroid cancer (PTC) is the most common form of thyroid cancer, comprising 80% of all thyroid malignancies. The phosphoinositide-3-kinase-protein kinase B/Akt (PI3K-PKB/Akt) pathway is a main pathway in control of cell growth. Activated mTOR and Akt are involved in the development and progression of the PTC.

The relationships between maternal and placental polymorphisms of miR-196a2 and miRNA-499 genes and preeclampsia.

: miRNAs are small non-coding RNAs with potential roles in the complications of pregnancy. We hypothesised links between polymorphisms in miRNA-196a2 and miRNA-499 in maternal blood and the placentas of patients with preeclampsia. : The blood of 315 women with preeclampsia and 317 controls and the placentas of 103 PE and 133 healthy women were collected.