Publications by authors named "M Artesi"
Article Synopsis
- The study focuses on the lesser-known phenomenon of oligogenic coinheritance, where individuals carry multiple heterozygous pathogenic variants (PVs) related to cancer, as opposed to the more commonly researched single gene carriers.
- Researchers examined 10 patients aged 45 or younger who had multiple primary cancers (MPCs) and used advanced genetic testing methods such as whole exome sequencing (WES) and chromosomal microarray analysis (CMA) to identify genetic variations associated with their conditions.
- The findings revealed that most genetic variants were of uncertain significance, indicating potential additive effects in cancer development, and emphasized the need for comprehensive assessments that go beyond just identifying one PV in patients with early-onset cancers and a family history of
Article Synopsis
- The study focuses on how SARS-CoV-2 evolves within immunocompromised patients, revealing new virus lineages resulting from prolonged infections, particularly the Omicron BF.7 sublineage that lasted over a year.
- Researchers analyzed eight samples from a single patient, discovering 87 genetic changes, including variants and deletions, indicating significant viral diversity within different parts of the respiratory system.
- The findings suggest that nasopharyngeal samples alone may not accurately reflect the full range of viral mutations, underlining the complexity of viral evolution in chronic infections.
Five to ten percent of mammalian genomes is occupied by multiple clades of endogenous retroviruses (ERVs), that may count thousands of members. New ERV clades arise by retroviral infection of the germline followed by expansion by reinfection and/or retrotransposition. ERV mobilization is a source of deleterious variation, driving the emergence of ERV silencing mechanisms, leaving "DNA fossils".
View Article and Find Full Text PDFMathematical modelling studies have shown that repetitive screening can be used to mitigate SARS-CoV-2 transmission in primary schools while keeping schools open. However, not much is known about how transmission progresses within schools and whether there is a risk of importation to households. During the academic year 2020-2021, a prospective surveillance study using repetitive screening was conducted in a primary school and associated households in Liège (Belgium).
View Article and Find Full Text PDFHealthcare workers (HCWs) are known to be at higher risk of developing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections although whether these risks are equal across all occupational roles is uncertain. Identifying these risk factors and understand SARS-CoV-2 transmission pathways in healthcare settings are of high importance to achieve optimal protection measures. We aimed to investigate the implementation of a voluntary screening program for SARS-CoV-2 infections among hospital HCWs and to elucidate potential transmission pathways though phylogenetic analysis before the vaccination era.
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