Publications by authors named "M Arsenault"
Article Synopsis
- Bicuspid aortic valve (BAV) shows increased progression of aorta dilation compared to tricuspid aortic valve (TAV) in patients with aortic stenosis, with a median annualized change of 0.33 mm/year for BAV versus 0.21 mm/year for TAV.
- Factors influencing the dilation rate differ by valve type; BAV patients are more affected by low-density lipoprotein (LDL) levels, while TAV patients are influenced by the apolipoprotein B/A-I ratio and baseline aortic jet velocity.
- The study highlights that men and women have different predictors for AA dilation; men’s dilation relates to baseline jet velocity and aortic diameter, while
Background: Little is known about the effect of sex on functional status decline in aortic valve stenosis (AS) patients.
Objectives: The purpose of this study was to examine the changes in functional status according to sex in patients with mild-to-moderate AS and its association with the composite of death or aortic valve replacement (AVR).
Methods: We included patients with mild-to-moderate AS prospectively recruited in the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) study (NCT01679431).
Plasma and Myocardial miRNomes Similarities and Differences during Cardiac Remodelling and Reverse Remodelling in a Murine Model of Heart Failure with Preserved Ejection Fraction.
Biomolecules
July 2024
Article Synopsis
- Heart failure with preserved ejection fraction (HFpEF) is influenced by various risk factors that affect organs beyond the heart, and a study used a mouse model to explore the effects of metabolic-hypertensive stress and exercise on heart health.
- After a period of stress, the study found that stopping the stresses and introducing voluntary exercise led to significant cardiac improvements, especially in female mice who experienced loss of cardiac hypertrophy and remodeling.
- The research also revealed changes in plasma microRNA levels (miRs), which changed in response to stress; however, while plasma levels normalized after recovery, the heart tissue showed persistent abnormalities, indicating that circulatory markers alone may not provide a complete picture of heart health recovery.
Background: Thresholds of aortic valve calcification (AVC) to define hemodynamically moderate aortic stenosis (AS) from mild are lacking. We aimed to establish a novel grading classification of AVC as quantified by computed tomography and determine its prognostic value.
Methods And Results: This study included 915 patients with at least mild AS (mean age 70±12 years, 30% women) from a multicenter prospective registry.
We propose a new mouse (C57Bl6/J) model combining several features of heart failure with preserved ejection fraction encountered in older women, including hypertension from Angiotensin II infusion (AngII), menopause, and advanced age. To mimic menopause, we delayed ovariectomy (Ovx) at 12 months of age. We also studied the effects of AngII infusion for 28 days in younger animals and the impact of losing gonadal steroids earlier in life.
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