Publications by authors named "M Arreola"
The pathogenesis of Alzheimer's disease (AD) depends on environmental and heritable factors, with its molecular etiology still unclear. Here we present a spatial transcriptomic (ST) and single-nucleus transcriptomic survey of late-onset sporadic AD and AD in Down syndrome (DSAD). Studying DSAD provides an opportunity to enhance our understanding of the AD transcriptome, potentially bridging the gap between genetic mouse models and sporadic AD.
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- The study investigates how cellular metabolism changes during hematopoiesis, focusing on the effects of mitochondrial adenylate kinase 2 (AK2) deficiency in a severe immunodeficiency syndrome called reticular dysgenesis.
- Using patient samples and CRISPR-modified human hematopoietic stem cells, the research reveals that AK2 deficiency affects mTOR signaling differently in early versus late granulocyte development, demonstrating the importance of metabolic checkpoints.
- While early-stage AK2-deficient cells maintain survival due to effective metabolic regulation, late-stage cells experience unchecked mTOR activity and energy depletion, leading to proliferation arrest and cell death.
Insulin receptor signaling promotes cell differentiation, proliferation, and growth which are essential for oocyte maturation, embryo implantation, endometrial decidualization, and placentation. The dysregulation of insulin signaling in women with metabolic syndromes including diabetes exhibits poor pregnancy outcomes that are poorly understood. We utilized the Cre/LoxP system to target the tissue-specific conditional ablation of insulin receptor () and insulin-like growth factor-1 receptor () using an anti-Mullerian hormone receptor 2 () Cre-driver which is active in ovarian granulosa and uterine stromal cells.
View Article and Find Full Text PDFBackground/objectives: High-risk Hodgkin lymphoma (HRHL) in children is curable with combined modality therapy. The Association of Pediatric Hematology-Oncology of Central America (AHOPCA) is a consortium of cancer centers from Central America. In 2004, AHOPCA implemented a guideline with a short course of chemotherapy (mStanfordV), strict diagnostics, and radiation guidelines, aimed at reducing abandonment and improving outcomes.
View Article and Find Full Text PDFSt. Tammany Parish Mosquito Abatement District relies on ultra-low volume (ULV) insecticides to manage adult Culex quinquefasciatus (Say 1823), the primary vector of West Nile virus in Louisiana, but abundance rarely declines post-treatment. Three field ULV applications each of adulticides containing deltamethrin, naled, or resmethrin were conducted from May through October 2022 to measure efficacy against free-flying Cx.
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