Publications by authors named "M Arleevskaya"
Patients with rheumatoid arthritis (RA) are prone to develop infections. Accordingly, 195 untreated early (e)RA patients and 398 healthy controls were selected from women in Tatarstan's cohort to study infectious history in the anamnesis (four criteria) and in the previous year (16 criteria). Information about annual infections was collected face-to-face from year to year by a qualified rheumatologist/general practitioner and included the active use of information from medical records.
View Article and Find Full Text PDFBackground: A familial history of rheumatoid arthritis (RA) predisposes an individual to develop RA. This study aimed at investigating factors associated with this conversion from the Tatarstan cohort.
Methods: A total of 144 individuals, referred to as pre-RA and at risk for familial RA, were selected 2 years (range: 2-21 years) before conversion to RA and compared to non-converted 328 first-degree relatives (FDR) from RA as assessed after ≥2 years follow-up, and 355 healthy controls were also selected (HC).
T cells are known to be involved in the pathogenesis of rheumatoid arthritis (RA). Accordingly, and to better understand T cells' contribution to RA, a comprehensive review based on an analysis of the Immune Epitope Database (IEDB) was conducted. An immune CD8+ T cell senescence response is reported in RA and inflammatory diseases, which is driven by active viral antigens from latent viruses and cryptic self-apoptotic peptides.
View Article and Find Full Text PDFArticle Synopsis
- Changes in the oral microbiome occur at the onset of rheumatoid arthritis (RA), but the microbiome's state before RA in individuals with clinically suspect arthralgia (CSA) is still unclear.
- A study involving Tatarstan women analyzed oral samples from various CSA stages and established RA patients, revealing decreased levels of specific bacterial genera in ACPA-positive individuals, especially those with early RA.
- Findings indicate a relationship between changes in the oral microbiome and ACPA levels, suggesting a need for further research into how ACPA influences the oral microbiome in RA patients.