Pheochromocytoma: clinical observations from a Brooklyn tertiary hospital.

Objective: To report eight cases of pheochromocytoma, diagnosed and treated at our tertiary hospital during a 42-month period.

Methods: We review clinical manifestations as well as historical and family data. Biochemical and radiologic methods for diagnosis and tumor localization at our institution were compared with methods at other teaching centers.

Ketoconazole reverses hyperandrogenism in a patient with insulin resistance and acanthosis nigricans.

We administered ketoconazole to a young woman with ovarian hyperandrogenism, insulin resistance, and acanthosis nigricans. While taking ketoconazole, her serum testosterone, androstenedione, dehydroepiandrosterone, and cortisol levels declined, while serum progesterone, 17-hydroxyprogesterone, and 11-deoxycortisol rose. Serum LH, FSH, and estradiol levels were intermittently higher during ketoconazole treatment, although LH and FSH responsiveness to GnRH did not change.