Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis.

Objective: The inflammatory responses from synovial fibroblasts and macrophages and the mitochondrial dysfunction in chondrocytes lead to oxidative stress, disrupt extracellular matrix (ECM) homeostasis, and accelerate the deterioration process of articular cartilage in osteoarthritis (OA). In recent years, it has been proposed that mesenchymal stromal cells (MSC) transfer their functional mitochondria to damaged cells in response to cellular stress, becoming one of the mechanisms underpinning their therapeutic effects. Therefore, we hypothesize that a novel cell-free treatment for OA could involve direct mitochondria transplantation, restoring both cellular and mitochondrial homeostasis.

Latitudinal changes in blubber fatty acids of the South American sea lion along the Southeast Pacific Coast.

The composition of marine mammal blubber is influenced by factors such as diet and environmental conditions. Here, we investigate the thermal influence on fatty acid composition and degree of unsaturation in the blubber of 151 South American sea lions (Otaria byronia). Samples were collected at ten locations along the Chilean coast and spanned a latitudinal range of approximately 2500 km, an arc of 23°.

Economic inequalities in adolescents' internalising symptoms: longitudinal evidence from eight countries.

Background: Research, mainly conducted in Europe and North America, has shown an inequitable burden of internalising mental health problems among adolescents from poorer households. We investigated whether these mental health inequalities differ across a diverse range of countries and multiple measures of economic circumstances.

Methods: In this longitudinal observational cohort study, we analysed data from studies conducted in eight countries (Australia, Ethiopia, India, Mexico, Peru, South Africa, the UK, and Viet Nam) across five global regions.

Comprehensive Assessment of Anti-Inflammatory, Antiproliferative and Neuroprotective Properties of Cauliflower after Dehydration by Different Drying Methods.

Cauliflower ( L. var. Botrytis Linnaeus) has various health benefits due to its rich bioactive compound content.