Publications by authors named "M Arando"
Article Synopsis
- * The researchers identified 96 TPA-positive samples, finding 47.9% were SS14-like and 52.1% were Nichols-like, revealing a notable increase in Nichols-like strains compared to previous data.
- * All samples displayed mutations linked to resistance against macrolide antibiotics, while none showed tetracycline resistance, highlighting the need for ongoing surveillance to track syphilis strain variations and improve public health responses.
Background: Management of syphilis, a sexually transmitted infection (STI) with increasing incidence, is challenged by drug shortages, scarcity of randomised trial data, an absence of non-penicillin alternatives for pregnant women with penicillin allergy (other than desensitisation), extended parenteral administration for neurosyphilis and congenital syphilis, and macrolide resistance. Linezolid was shown to be active against Treponema pallidum, the causative agent of syphilis, in vitro and in the rabbit model. We aimed to assess the efficacy of linezolid for treating early syphilis in adults compared with the standard of care benzathine penicillin G (BPG).
View Article and Find Full Text PDFObjectives: Culture of remains essential for antimicrobial resistance (AMR) surveillance. We evaluated the effect of time of specimen collection on culture yield following a positive nucleic acid amplification test (NAAT).
Methods: We retrospectively assessed culture yield among asymptomatic individuals (largely men who have sex with men) who attended for sexual health screening and had a positive NAAT.
To assess the feasibility of oral fosfomycin-tromethamine (FT) for the management of acute bacterial prostatitis (ABP) caused by multidrug-resistant (MDR) Enterobacterales. An observational study of adult patients diagnosed with ABP from Vall d'Hebron University Hospital (Barcelona, Spain), treated with oral FT. The primary outcome was clinical cure defined as symptom relief at the control visit, 2-4 weeks post-end of treatment.
View Article and Find Full Text PDFObjectives: We aimed to determine if starting antiretroviral therapy (ART) in the first 30 days after acquiring HIV infection has an impact on immunovirological response.
Methods: Observational, ambispective study including 147 patients with confirmed acute HIV infection (January/1995-August/2022). ART was defined as very early (≤30 days after the estimated date of infection), early (31-180 days), and late (>180 days).