Publications by authors named "M Aquilano"
is responsible for the direct repair of O6-methylguanine lesions induced by alkylating agents, including temozolomide. promoter hypermethylation is a well-established biomarker for temozolomide response in glioblastoma patients, also correlated with therapeutic response in colorectal cancer. The ARETHUSA clinical trial aims to stratify colorectal cancer patients based on their mismatch repair status.
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- The study highlights the interest in PARP inhibitors for treating tumors with "BRCAness," particularly in colorectal cancers, as approximately 15% possess defects in the homologous recombination (HR) pathway, presenting new treatment opportunities.
- The researchers developed HRDirect, an advanced tool for predicting HR deficiency (HRD) in tumor samples, which outperformed existing assays by accurately identifying resistant colorectal cancer models.
- The study suggests a composite biomarker approach combining HRDirect scoring with ATM and RAD51C analysis to improve HRD tumor identification and enhance personalized treatment strategies for colorectal cancer patients.
Background: Intraluminal non-occlusive thrombus (ILT) is a rare cause of ischemic stroke. Although in most cases ILT is associated with arterial wall disorders, it has also been documented in patients with thrombophilic conditions.
Case Report: We present a case of carotid ILT in a 38-year-old puerperal woman with pregnancy-induced hypercoagulability.
The bacterial genotoxin colibactin promotes colorectal cancer (CRC) tumorigenesis, but systematic assessment of its impact on DNA repair is lacking, and its effect on response to DNA-damaging chemotherapeutics is unknown. We find that CRC cell lines display differential response to colibactin on the basis of homologous recombination (HR) proficiency. Sensitivity to colibactin is induced by inhibition of ATM, which regulates DNA double-strand break repair, and blunted by HR reconstitution.
View Article and Find Full Text PDFBackground: Endovascular thrombectomy (EVT) is a treatment option in patients with a cerebral venous thrombosis (CVT) who deteriorate despite anticoagulant treatment. Assessment of thrombus composition in CVT may provide insights into the pathophysiology of the disease and suggest new therapeutic strategies.
Case Report: A 47-year-old woman (smoking habit and estradiol/progesterone-releasing intra-uterine device) diagnosed with massive CVT underwent EVT (complete recanalization via aspiration catheter and stentriever) due to acute-onset left-sided weakness and dysarthria despite 72 h of full-dose subcutaneous low-molecular heparin.