PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis.

Cell cycle progression is regulated by the orderly balance between kinase and phosphatase activities. PP2A phosphatase holoenzymes containing the B55 family of regulatory B subunits function as major CDK1-counteracting phosphatases during mitotic exit in mammals. However, the identification of the specific mitotic roles of these PP2A-B55 complexes has been hindered by the existence of multiple B55 isoforms.

Acute pancreatitis secondary to migration and impaction of an intragastric balloon.

Obesity represents a significant global health problem, and reducing its alarmingly high incidence is an urgent challenge. The intragastric balloon is a safe and effective device for weight loss; therefore, it is widely used. Although the frequency of serious complications resulting from its use is low, it is not exempt from them.

Mechanism of Action of , a New Bacterial Species with Probiotic Potential.

is a recently reported bacterial species of oral origin, with inhibitory capacity against , , and , which confers upon it the potential of being an oral probiotic. The aim of the present study was to identify the potential mechanisms by which exerts its inhibitory effect on . To this end, the study assessed the consumption of glucose and proteins available in the culture medium, the modification of the pH, the production of short-chain fatty acids, the changes in the protein panel of the inhibition halo, the production of hydrogen peroxide and the effect of proteinase K.

Spectral CT as a method for identifying radiolucent gallstones.

We present the case of an 82-year-old woman with history of right colon adenocarcinoma in whom a routine control scan is performed using a dual-layer detector spectral CT scanner. Conventional CT scan images show a dilated cystic bile duct with no apparent cause of obstruction, finding also no lithiasis inside the gallbladder. Non-calcified gallstones are composed mainly of cholesterol and can have the same radiographic density as bile, making them hard or impossible to spot on conventional CT.

Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer.

Metastatic prostate cancer (PCa) inevitably acquires resistance to standard therapy preceding lethality. Here, we unveil a chromosomal instability (CIN) tolerance mechanism as a therapeutic vulnerability of therapy-refractory lethal PCa. Through genomic and transcriptomic analysis of patient datasets, we find that castration and chemotherapy-resistant tumors display the highest CIN and mitotic kinase levels.