Publications by authors named "M Anouk"
Objective: To investigate the effects of methotrexate (MTX) and the tumour necrosis factor inhibitor infliximab (IFX) on immune cells derived from peripheral blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs) of inflammatory arthritis patients.
Method: Phytohaemagglutinin (PHA)-induced proliferation of healthy donors' PBMCs and synovial intermediate monocytes (CD14CD16 cells) in SFMCs derived from psoriatic arthritis (PsA) and rheumatoid arthritis (RA) patients was determined by flow cytometry following co-culture with IFX and MTX. PHA-induced interferon-γ (IFN-γ) production in PBMCs was measured by enzyme-linked immunosorbent assay.
Article Synopsis
- Synovial monocytes (CD14+CD16+) play a key role in the inflammatory responses in patients with psoriatic arthritis (PsA) and rheumatoid arthritis (RA), and the study investigates the impact of different drugs on these cells.
- In laboratory tests, TNF inhibitors (adalimumab and infliximab) significantly decreased the percentage of CD14+CD16+ cells and reduced TNF levels in PsA and RA patients compared to other treatments, such as IL-17 inhibitors and glucocorticoids.
- Additionally, while TNF inhibitors down-regulated inflammatory cytokines and increased anti-inflammatory ones, glucocorticoids had mixed effects, changing the expression of genes related to inflammation differently
Behçet disease (BD) is a multisystemic disease that commonly involves the eyes. Although it affects patients in all age groups, data on ocular disease by age of onset are limited. This retrospective, multicenter study aimed to compare epidemiology, systemic and ocular manifestations, treatments and outcomes between three age groups: juvenile (<18 years), adult (18-39 years) and late (≥40 years) disease onset.
View Article and Find Full Text PDFPurpose: The literature on retinal vascular occlusions in Behçet disease (BD) patients is limited. The aim of this study is to thoroughly investigate retinal vascular occlusions among ocular BD patients.
Methods: Retrospective, multicentre case-control study.
Objective: To investigate whether ultrasonography (US), as an objective imaging modality, can optimise the evaluation of disease activity in psoriatic arthritis (PsA) patients with concomitant fibromyalgia syndrome (FMS).
Methods: The study population included 156 consecutive PsA patients who were recruited prospectively and fulfilled the ClASsification criteria for Psoriatic ARthritis criteria. The patients underwent complete clinical evaluation including assessment of fulfilment of the 2016 fibromyalgia classification criteria.