Publications by authors named "M Angriman"
The manifestations of chronic insomnia undergo age-related changes. In younger infants and children, behavioral insomnia emerges as the most prevalent form and typically responds to behavioral interventions. However, distinct clusters of clinical presentations suggest the presence of various phenotypes, potentially implicating the primary involvement of specific neurotransmitters.
View Article and Find Full Text PDFWe conducted the first scientometric analysis to quantitatively assess the scientific contribution of researchers from Italian institutions in the field of pediatric sleep medicine. We searched Science Citation Index Expanded from Web of Science (WOS) Science Citation up to November 3rd, 2022. Bibliometrix R packages (3.
View Article and Find Full Text PDFChronic insomnia of early childhood: Phenotypes and pathophysiology.
Neurosci Biobehav Rev
June 2022
This paper aims to review the limitations of the current classification of insomnia of early childhood and propose a new conceptual model allowing a better understanding of its pathophysiology. Our hypothesis is that chronic insomnia of childhood has different phenotypical expressions, associated to different pathophysiological mechanisms. Based on a long-lasting experience in evaluating a very large number of children with specific insomnia symptoms (nocturnal awakenings, difficulty in falling asleep, nocturnal restlessness, early morning awakenings) and on published data, we hypothesize that different phenotypes of insomnia might exist with different therapeutic implications.
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- This study investigates the impact of alarmed intermittently scanned continuous glucose monitoring (isCGM) on sleep quality and metabolic control in children and adolescents with type 1 diabetes (T1D).
- Researchers monitored 47 patients using two types of isCGM devices over a 28-day period, with one group using alarms (Freestyle Libre 2) and the other without (Freestyle Libre 1).
- The results showed improved glucose management with the alarm system, revealing a slight increase in Time In Range and a decrease in hypoglycemic events, while sleep quality remained consistent, and parents reported enhanced Quality of Life.
Article Synopsis
- The study focuses on identifying de novo pathogenic variants in epilepsy patients to improve management and prognostic understanding.
- A cohort of 34 patients from Italy, Denmark, and Belgium showed that although many had severe cognitive disabilities, a significant portion were able to achieve seizure freedom.
- The research identified 28 variants primarily in conserved regions of a protein; however, it found no clear correlation between the location of these variants and the clinical outcomes, indicating the need for further investigation into the complexity of genetic impacts.