Molecular Iodine-Mediated β-Glycosylation of Thiomannosides with 1,6-Anhydrosugars.

β-Mannosides play a crucial role in cellular processes and immune responses, and their synthesis remains one of the most challenging tasks in carbohydrate chemistry. Glycosyl donors, such as thiomannosides, are stable and compatible with a range of protection and deprotection conditions. In this study, we demonstrate that molecular iodine efficiently induces the activation and coupling of thiomannosides with various 1,6-anhydrosugars as acceptors.

Maternal genomic profile, gestational diabetes control, and Mediterranean diet to prevent low birth weight.

Low birth weight (LBW) is associated to poor health outcomes. Its causes include maternal lifestyle, obstetric factors, and fetal (epi)genetic abnormalities. This study aims to increase the knowledge regarding the genetic background of LBW by analyzing its association with a set of 110 maternal variants related to gestational diabetes mellitus, in the setting of a nutritional intervention with Mediterranean diet.

Development and validation of a multivariable genotype-informed gestational diabetes prediction algorithm for clinical use in the Mexican population: insights into susceptibility mechanisms.

Introduction: Gestational diabetes mellitus (GDM) is underdiagnosed in Mexico. Early GDM risk stratification through prediction modeling is expected to improve preventative care. We developed a GDM risk assessment model that integrates both genetic and clinical variables.

Genetic variants for prediction of gestational diabetes mellitus and modulation of susceptibility by a nutritional intervention based on a Mediterranean diet.

Hypothesis: Gestational diabetes mellitus (GDM) entails a complex underlying pathogenesis, with a specific genetic background and the effect of environmental factors. This study examines the link between a set of single nucleotide polymorphisms (SNPs) associated with diabetes and the development of GDM in pregnant women with different ethnicities, and evaluates its potential modulation with a clinical intervention based on a Mediterranean diet.

Methods: 2418 women from our hospital-based cohort of pregnant women screened for GDM from January 2015 to November 2017 (the San Carlos Cohort, randomized controlled trial for the prevention of GDM ISRCTN84389045 and real-world study ISRCTN13389832) were assessed for evaluation.