Enhancing mortality prediction in patients with spontaneous intracerebral hemorrhage: Radiomics and supervised machine learning on non-contrast computed tomography.

Purpose: This study aims to develop a Radiomics-based Supervised Machine-Learning model to predict mortality in patients with spontaneous intracerebral hemorrhage (sICH).

Methods: Retrospective analysis of a prospectively collected clinical registry of patients with sICH consecutively admitted at a single academic comprehensive stroke center between January-2016 and April-2018. We conducted an in-depth analysis of 105 radiomic features extracted from 105 patients.

Sensory Navigation System for Indoor Localization and Orientation of Users with Cognitive Disabilities in Daily Tasks and Emergency Situations.

This article presents SmartRoutes, (version 1) a sensory navigation system designed for the localization and guidance of individuals with cognitive disabilities in both indoor and outdoor environments. The platform facilitates route generation in both contexts and provides detailed instructions, enabling effective task execution and seamless integration into daily activities or high-stress situations, such as emergency evacuations. SmartRoutes aims to enhance users' independence and quality of life by offering comprehensive support for navigation across various settings.

Challenges and Opportunities in COPD Management in Latin America: A Review of Inhalation Therapies and Advanced Drug Delivery Systems.

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, particularly in low- and middle-income countries, where it poses a significant burden. In Latin America, the estimated prevalence of COPD is notably high, but the management and treatment of the disease have progressed slowly. This review examines the current status of inhalation therapy for COPD in Latin America, focusing on pharmacological therapies, inhalation devices, and the potential of advanced drug delivery systems.

Bismuth-based drugs sensitize Pseudomonas aeruginosa to multiple antibiotics by disrupting iron homeostasis.

Pseudomonas aeruginosa infections are difficult to treat due to rapid development of antibiotic drug resistance. The synergistic combination of already-in-use drugs is an alternative to developing new antibiotics to combat antibiotic-resistant bacteria. Here we demonstrate that bismuth-based drugs (bismuth subsalicylate, colloidal bismuth subcitrate) in combination with different classes of antibiotics (tetracyclines, macrolides, quinolones, rifamycins and so on) can eliminate multidrug-resistant P.

Validation of an IMU-based Gait Analysis Method for Assessment of Fall Risk Against Traditional Methods.

Falls are a severe problem in older adults, often resulting in severe consequences such as injuries or loss of consciousness. It is crucial to screen fall risk in order to prescribe appropriate therapies that can potentially prevent falls. Identifying individuals who have experienced falls in the past, commonly known as fallers, is used to evaluate fall risk, as a prior fall indicates a higher likelihood of future falls.