Publications by authors named "M Angeles Mantecon"
Aging is associated with central fat redistribution and insulin resistance. To identify age-related adipose features, we evaluated the senescence and adipogenic potential of adipose-derived stromal cells (ASCs) from abdominal subcutaneous fat obtained from healthy normal-weight young (<25 years) or older women (>60 years). Increased cell passages of young-donor ASCs (in vitro aging) resulted in senescence but not oxidative stress.
View Article and Find Full Text PDFBackground: COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus.
View Article and Find Full Text PDFBackground: Catheter-related bloodstream infections (CRBSIs) increase morbidity and mortality, prolong hospitalization and generate considerable medical costs. Recent guidelines for CRBSI recommend empirical therapy against Gram-positive bacteria (GPB) and restrict coverage for Gram-negative bacteria (GNB) only to specific circumstances.
Objectives: To investigate predictors of GNB aetiology in CRBSI and to assess the predictors of outcome in patients with CRBSI.
Article Synopsis
- - Aging is linked to fat tissue issues like inflammation and fibrosis, and HIV-infected individuals, particularly older ones, have a greater risk of trunk fat gain, indicating that the virus may affect fat tissue aging and function.
- - Research on SIV-infected macaques and human adipose stem cells showed that viral proteins Tat and Nef increased signs of fat tissue aging and dysfunction, including oxidative stress and mitochondrial problems.
- - The presence of HIV/SIV appears to accelerate fat tissue aging, potentially leading to altered fat cell functions and increased insulin resistance.
The Integrase Inhibitors Dolutegravir and Raltegravir Exert Proadipogenic and Profibrotic Effects and Induce Insulin Resistance in Human/Simian Adipose Tissue and Human Adipocytes.
Clin Infect Dis
December 2020
Background: Although some integrase strand transfer inhibitors (INSTIs) promote peripheral and central adipose tissue/weight gain in people with human immunodeficiency virus (PHIV), the underlying mechanism has not been identified. Here, we used human and simian models to assess the impact of INSTIs on adipose tissue phenotype and function.
Methods: Adipocyte size and fibrosis were determined in biopsies of subcutaneous and visceral adipose tissue (SCAT and VAT, respectively) from 14 noninfected macaques and 19 PHIV treated or not treated with an INSTI.