Analysis of Thiodiphenol in Rat Urine as a Biomarker of Exposure to Temephos.

Temephos is an organophosphorus pesticide widely used as a larvicide in public health campaigns to control vector-borne diseases. Data on the urinary elimination of temephos metabolites are limited, and there is no validated biomarker of exposure for its evaluation. This study aimed to determine the urinary excretion kinetics of temephos and its metabolites in adult male rats.

Exposome Determinants of Quality of Life in Adults Over 50: Personality Traits, Childhood Conditions, and Long-Term Unemployment in SHARELIFE Retrospective Panel.

Introduction: The present research applies the exposome approach for understanding Quality of life of +50 Europeans based on retrospective panel data. Our paper explores the cumulative influences of personality traits, childhood adversities, such as poor health in infancy, culturally deprived environments, poor mathematical performance, or reduced language skills, and undesired employment status along the life course on Quality of Life of +50 Europeans.

Methods: The study utilizes data from the SHARE (Survey of Health, Aging and Retirement in Europe), belonging to SHARELIFE (wave 3 and 7) and from the Working Life Histories retrospective panel (N = 5884).

Towards a Multi-Stakeholder process for developing responsible AI governance in consumer health.

Introduction: AI is big and moving fast into healthcare, creating opportunities and risks. However, current approaches to governance focus on high-level principles rather than tailored recommendations for specific domains like consumer health. This gap risks unintended consequences from generic guidelines misapplied across contexts and from providing answers before agreeing on the questions.

Phase 2, Multicenter, Open-label, Nonrandomized Study of Neoadjuvant Chemotherapy Liposomal Irinotecan With 5-Fluorouracil, Leucovorin, and Oxaliplatin, Followed by Chemoradiotherapy in Patients With Rectal Cancer in a Watch-and-Wait Program.

Objective: To evaluate the efficacy of neoadjuvant chemotherapy combination with liposomal irinotecan, 5-fluorouracil, leucovorin, and oxaliplatin in patients with locally advanced rectal cancer.

Methods: This was a phase 2, nonrandomized, multicenter study in adults with stage II or III rectal cancer and an Eastern Cooperative Oncology Group performance status of 0 to 1. Total neoadjuvant therapy (TNT) consisted of neoadjuvant chemotherapy combination with liposomal irinotecan (60 mg/m2), oxaliplatin (60 mg/m2), leucovorin (400 mg/m2), and fluorouracil (2400 mg/m²), followed by chemoradiotherapy [ie, capecitabine (825 mg/m2) and radiotherapy according to the standard of care].

Hypothalamic Regulation of Cardiorespiratory Functions: Insights into the Dorsomedial and Perifornical Pathways.

The plays a pivotal role in the orchestration of sympathetic nervous system activities. Through its projections to the brainstem and pontomedullary nuclei, it controls heart rate, contractility, blood pressure, and respiratory activity, such as timing and volumes. The DMH integrates inputs from higher brain centers and processes these signals in order to modulate autonomic outflow accordingly.