Publications by authors named "M Angeles Castillejo"
Peanut production could be increased through plant growth-promoting rhizobacteria (PGPR). In this regard, the present field research aimed at elucidating the impact of PGPR on peanut yield, soil enzyme activity, microbial diversity, and structure. Three PGPR strains (, RI3; , SC6; , P10) were evaluated, along with (BJ), taken as a control.
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- DNA methylation plays a crucial role in plant growth and adaptability, yet it is under-researched in holm oak and other non-domesticated forest trees.
- The study identified 13 DNA methyltransferase and 3 demethylase genes, with varying expression levels across different plant organs and developmental stages, showing that adult leaves have higher global DNA methylation levels.
- Methylation patterns predominantly affected nuclear genes, particularly in regions associated with essential biological processes like photosynthesis and defense mechanisms, highlighting the importance of epigenetic variation in holm oak.
Background: Treatment of castration-resistant metastatic prostate cancer with [¹⁷⁷Lu]PSMA radioligand.
Case Presentation: A man in his seventies with metastatic prostate cancer received castration therapy for four years, developing castration-resistant disease. PET/CT with [⁶⁸Ga]PSMA-11 showed high uptake in metastatic lymph nodes.
Article Synopsis
- Prostate-specific membrane antigen (PSMA) PET significantly enhances management decisions for patients with biochemically recurrent prostate cancer by revealing more positive findings compared to MRI and CT alone.
- The study analyzed data from 41 patients, showing that the combination of PET with either MRI or CT led to improved detection rates and altered treatment plans for a considerable number of patients.
- The interreader agreement improved significantly with the addition of PET, highlighting its importance in clinical assessment and decision-making.
Article Synopsis
- Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) is a rare genetic condition linked to mutations in the FH gene, with a prevalent mutation identified in a large cohort from Spain.
- The study confirmed that a common variant, FH c.1118A > G p.(Asn373Ser), likely originated from a single ancestor 12-26 generations ago, causing specific health issues such as uterine leiomyomatosis and renal cell cancer in affected individuals.
- In Alicante, Spain, this founder mutation is prevalent, and genetic testing for this specific mutation is suggested as a more efficient diagnostic method than full gene sequencing for those suspected of having HLRCC.