Levodopa Equivalent Daily Dosage: Geographical Variations and Real-Life Modules in Parkinson's Disease.

Background: The Levodopa Equivalent Daily Dosage (LEDD) calculation algorithms help in capturing and harmonization of Parkinson's Disease (PD) therapies. Analyzing these updates is essential for validating their effectiveness.

Objective: To assess updated LEDD conversion factors in capturing the newer therapies in PD and therapy modules in different geographical cohorts.

Coordinated ARP2/3 and glycolytic activities regulate the morphological and functional fitness of human CD8 T cells.

Actin cytoskeleton remodeling sustains the ability of cytotoxic T cells to search for target cells and eliminate them. We here investigated the relationship between energetic status, actin remodeling, and functional fitness in human CD8 effector T cells. Cell spreading during migration or immunological synapse assembly mirrored cytotoxic activity.

Neurological disorders associated with COVID-19 in Sri Lanka.

Background: Neurological manifestations of SARS-CoV-2 infection have been reported from many countries around the world, including the South Asian region. This surveillance study aimed to describe the spectrum of neurological disorders associated with COVID-19 in Sri Lanka.

Methods: COVID-19 patients manifesting neurological disorders one week prior and up to six weeks after infection were recruited from all the neurology centres of the government hospitals in Sri Lanka from May 2021 - May 2022.

Covid-19 emergency management and preparedness in cross-border territories. Collection of experiences, needs and public health strategies in the framework of interreg GESTI.S.CO. project.

Background And Aim: The Covid-19 pandemic highlighted management difficulties in neighboring territories. The aim of the paper is to report the needs of different stakeholders during, before and after Covid-19 emergency with specific regard to challenges faced by public administrators in confined territories.

Methods: In the framework of Interreg GESTI.

A comparative study of the characteristics of hate speech propagators and their behaviours over Twitter social media platform.

The internet and social media have facilitated diverse communication genres, enabling widespread and rapid opinions-sharing. However, hate speech imposes a contemporary challenge on individuals and communities, given the user anonymity, freedom, and inadequate regulation. Therefore, it is imperative to identify the perpetrators responsible for spreading hate content and examine their behaviour to prevent and mitigate the negative impact.