Generalized expectancy of threat in threatening compared to safe contexts.

Fear of threatening contexts often generalizes to similar safe contexts, but few studies have investigated how contextual information influences cue generalization. In this study, we explored whether fear responses to cues would generalize more broadly in a threatening compared to a safe context. Forty-seven participants underwent a differential cue-in-context conditioning protocol followed by a generalization test, while we recorded psychophysiological and subjective responses.

Elemental and configural representation of a conditioned context.

A context can be conceptualized as a stable arrangement of elements or as the sum of single elements. Both configural and elemental representations play a role in associative processes. This study aimed to explore the respective contributions of these two representations of a context in the acquisition of conditioned anxiety in humans.

Trauma history and course of therapy in a naturalistic cognitive behavior therapy outpatient sample: An archive data study.

Objective: Cognitive Behavior Therapy (CBT) is an effective treatment for anxiety and depression disorders. Nonetheless, nearly 50% of all patients do not respond. Besides other factors, nonresponse may be linked to traumatic life events.

Semi-supervised integration of single-cell transcriptomics data.

Batch effects in single-cell RNA-seq data pose a significant challenge for comparative analyses across samples, individuals, and conditions. Although batch effect correction methods are routinely applied, data integration often leads to overcorrection and can result in the loss of biological variability. In this work we present STACAS, a batch correction method for scRNA-seq that leverages prior knowledge on cell types to preserve biological variability upon integration.