Publications by authors named "M Amparo F Faustino"
Article Synopsis
- Water pollution is a major global issue, particularly with antibiotic-resistant pathogens being a specific concern, which this study aims to address through Antimicrobial Photodynamic Therapy (aPDT).
- The study examines two types of chlorin derivatives, HChl 1a and ZnChl 1b, focusing on their synthesis, properties, and effectiveness in killing bacteria like Staphylococcus aureus and Escherichia coli when exposed to light.
- Results show that both chlorin derivatives significantly reduce bacterial viability at low concentrations, suggesting their promising role as photosensitizers in the fight against waterborne pathogens and for potential water remediation applications.
Antimicrobial resistance remains an enduring global health issue, manifested when microorganisms, such as bacteria, lack responsiveness to antimicrobial treatments. Photodynamic inactivation (PDI) of microorganisms arises as a noninvasive, nontoxic, and repeatable alternative for the inactivation of a broad range of pathogens. So, this study reports the synthesis, structural characterization, and photophysical properties of a new tetra-β-substituted pyridinium-pyrazolyl zinc(II) phthalocyanine (ZnPc ) that was compared with two previously described pyridinium-pyrazolyl ZnPcs and .
View Article and Find Full Text PDFA mathematical framework for genetic relatedness analysis involving X chromosome aneuploidies.
Forensic Sci Int Genet
January 2025
The unique features of the X chromosome can be crucial to complement autosomal profiling or to disentangle complex kinship problems, providing in some cases a similar or even greater power than autosomes in paternity/maternity investigations. While theoretical and informatics approaches for pairwise X-linked kinship analyses are well established for euploid individuals, these are still lacking for individuals with an X chromosome aneuploidy. To trigger the fulfilment of this gap, this research presents a mathematical framework that enables the quantification of DNA evidence in pairwise kinship analyses, involving two non-inbred individuals, one of whom with a non-mosaic X chromosome aneuploidy: Trisomy X (47, XXX), Klinefelter (47, XXY) or Turner (45, X0) syndrome.
View Article and Find Full Text PDFArticle Synopsis
- - Alzheimer's disease leads to cognitive decline and memory loss, linked to issues with the neurotransmitter acetylcholine, prompting interest in developing effective acetylcholinesterase (AChE) inhibitors.
- - New thiazoloindazole-based compounds have shown potential as AChE inhibitors, with some outperforming the existing treatment drug donepezil in molecular studies, and good synthesis yields of 66 to 87%.
- - The most promising derivatives feature a bis(trifluoromethyl)phenyl-triazolyl group, which effectively inhibits AChE, achieving remarkable inhibitor potency with an IC value below 1.0 μM.
Antimicrobial photodynamic treatment (aPDT) offers an alternative option for combating microbial pathogens, and in this way, addressing the challenges of growing antimicrobial resistance. In this promising and effective approach, cationic porphyrins and related macrocycles have emerged as leading photosensitizers (PS) for aPDT. In general, their preparation occurs via -alkylation of nitrogen-based moieties with alkyl halides, which limits the ability to fine-tune the features of porphyrin-based PS.
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