Predicting the Response of Patients Treated with Lu-DOTATATE Using Single-photon Emission Computed Tomography-Computed Tomography Image-based Radiomics and Clinical Features.

Background: In this study, we want to evaluate the response to Lutetium-177 (Lu)-DOTATATE treatment in patients with neuroendocrine tumors (NETs) using single-photon emission computed tomography (SPECT) and computed tomography (CT), based on image-based radiomics and clinical features.

Methods: The total volume of tumor areas was segmented into 61 SPECT and 41 SPECT-CT images from 22 patients with NETs. A total of 871 radiomics and clinical features were extracted from the SPECT and SPECT-CT images.

Radiomics Analysis for Clinical Decision Support in 177Lu-DOTATATE Therapy of Metastatic Neuroendocrine Tumors using CT Images.

Background: Radiomics is the computation of quantitative image features extracted from medical imaging modalities to help clinical decision support systems, which could ultimately meliorate personalized management based on individual characteristics.

Objective: This study aimed to create a predictive model of response to peptide receptor radionuclide therapy (PRRT) using radiomics computed tomography (CT) images to decrease the dose for patients if they are not a candidate for treatment.

Material And Methods: In the current retrospective study, 34 patients with neuroendocrine tumors whose disease is clinically confirmed participated.

Utility of Tc-Sestamibi Heart/Liver Uptake Ratio in Screening Nonalcoholic Fatty Liver Disease During Myocardial Perfusion Imaging.

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic hepatic disease worldwide, with functional impairment of the mitochondria occurring from early stages. Technetium-99m methoxy-isobutyl-isonitrile (Tc-MIBI) is a lipophilic agent trapped in the mitochondria. This study aims to evaluate the utility of Tc-MIBI heart/liver uptake ratio in screening for NAFLD during myocardial perfusion imaging (MPI).

An automatic segmentation framework for computer-assisted renal scintigraphy procedure.

One of the techniques for achieving unique and reliable information in medicine is renal scintigraphy. A key step for quantitative renal scintigraphy is segmentation of the kidneys. Here, an automatic segmentation framework was proposed for computer-aided renal scintigraphy procedures.

Comparison of Accuracy in Calculation of Absorbed Dose to the Kidneys Following Radioligand Therapy with Lu-DKFZ-PSMA-617 by Two Different Background Correction Methods.

Background: To improve the accuracy of activity image quality, scatter correction is a critical method. The aim of this study is to compare the accuracy in calculation of absorbed dose to patients following radioligand therapy (RLT) with Lu-DKFZ-PSMA-617 by two different methods of background correction in the conjugate view method.

Materials And Methods: This study involved 10 patients.