Publications by authors named "M Amishima"
Article Synopsis
- A study analyzed the rates and impact of respiratory bacterial infections in Japanese patients hospitalized with COVID-19, finding that 7.5% of patients experienced such infections.
- The most common causes of these infections included Staphylococcus aureus, Klebsiella pneumoniae, and Streptococcus pneumoniae, with more severe outcomes linked to hospital-acquired infections and pre-existing health conditions.
- The research highlights the importance of monitoring and assessing bacterial complications in COVID-19 patients, as these infections can significantly increase mortality rates.
Article Synopsis
- The study examined the impact of non-respiratory bacterial and fungal infections on hospitalized COVID-19 patients, focusing on the types of infections, their causative organisms, and their effects on mortality rates.
- Out of 1914 patients, 4.2% developed non-respiratory bacterial infections, predominantly bacteremia, which was linked to a higher risk of death, particularly in patients with certain predisposing factors.
- The findings highlight the need for effective medical strategies to manage secondary infections in COVID-19 patients, especially those at a greater risk, such as older individuals and those admitted to intensive care.
Article Synopsis
- * Researchers analyzed RNA-seq data from 465 blood samples, uncovering 1169 expression quantitative trait loci (eQTLs) and 1549 splice QTLs (sQTLs) linked to COVID-19 severity, including immune-related expressions.
- * The study highlights the impact of disease severity on gene expression, identifying specific eQTLs that interact with COVID-19 phenotypes, and provides an extensive resource for understanding gene regulation in response to the virus.
Article Synopsis
- Researchers conducted a genome-wide association study (GWAS) with 2,393 COVID-19 patients and 3,289 controls in Japan, identifying a specific genetic variant (rs60200309-A) on chromosome 5 linked to severe cases in individuals under 65.
- The variant is more common in East Asians and associated with reduced expression of the DOCK2 gene, which was found to be lower in severe COVID-19 cases, particularly in non-classical monocytes.
- Additionally, inhibiting DOCK2 in hamsters worsened pneumonia symptoms, indicating its potential as a biomarker and therapeutic target for severe COVID-19.
Background: The Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system aggregates information related to antimicrobial resistance (AMR) measures in participating medical institutions nationwide and is intended to be used for promotion of AMR measures in participating facilities and their communities. This multicenter study aimed to determine the usefulness of the J-SIPHE system for evaluating the correlation between antibiotic use and antibiotic resistance in Hokkaido, Japan.
Methods: Data on antibiotic use and detection rate of major resistant Gram-negative bacteria at 19 hospitals in 2020 were collected from the J-SIPHE system, and data correlations were analyzed using JMP Pro.