A novel missense variant in associated with nonobstructive azoospermia.

The most severe type of male infertility is nonobstructive azoospermia (NOA), where there is no sperm in the ejaculate due to failure of spermatogenesis. The predictable frequency of NOA in the general population is one in 100 men. Genetic studies have recognized dozens of NOA genes.

Metagenome sequence data mining for viral interaction studies: Review on progress and prospects.

Metagenomics has been greatly accelerated by the development of next-generation sequencing (NGS) technologies, which allow scientists to discover and describe novel microorganisms without the need for conventional culture techniques. Examining integrative bioinformatics methods used in viral interaction research, this study highlights metagenomic data from various contexts. Accurate viral identification depends on high-purity genetic material extraction, appropriate NGS platform selection, and sophisticated bioinformatics tools like VirPipe and VirFinder.

Long ties accelerate noisy threshold-based contagions.

In widely used models of biological contagion, interventions that randomly rewire edges (generally making them 'longer') accelerate spread. However, recent work has argued that highly clustered, rather than random, networks facilitate the spread of threshold-based contagions, such as those motivated by myopic best response for adoption of new innovations, norms and products in games of strategic complement. Here we show that minor modifications to this model reverse this result, thereby harmonizing qualitative facts about how network structure affects contagion.

Unveiling the nexus of climate change, adaptation strategies, and food security: Insights from small-scale farmers in zagros mountains in Iran.

In today's world, climate change and its unprecedented impact on food and nutrition security have emerged as a significant and formidable global challenge. This study aimed to investigate the effect of adaptation strategies on the food security of small-scale farmers in Khorramabad city, Iran, using a survey-based analysis. To assess the food security level, the Household Food Security Survey Module (HFSSM) was employed.