Publications by authors named "M Amiguet"
Objectives: This study investigates gender and sex disparities in COVID-19 epidemiology in the Canton of Vaud, Switzerland, focusing on the interplay with socioeconomic position (SEP) and age.
Methods: We analyzed COVID-19 surveillance data from March 2020 to June 2021, using an intersectional approach. Negative binomial regression models assessed disparities between women and men, across SEP quintiles and age groups, in testing, positivity, hospitalizations, ICU admissions, and mortality (Incidence Rate Ratios [IRR], with 95% Confidence Intervals [CI]).
The klotho and fibroblast growth factor 23 (FGF-23) pathway is implicated in cardiovascular pathophysiology. This substudy aimed to assess the changes in klotho and FGF-23 levels 1-month after dapagliflozin in patients with stable heart failure and reduced ejection fraction (HFrEF). The study included 29 patients (32.
View Article and Find Full Text PDFArticle Synopsis
- Some studies suggest SGLT2 inhibitors like dapagliflozin can impact how cells use iron, particularly in patients with heart failure and reduced ejection fraction (HFrEF).
- The study aimed to evaluate the effects of dapagliflozin on iron parameters and peak oxygen consumption (Vo) in HFrEF patients.
- Results showed dapagliflozin significantly decreased ferritin levels and increased peak Vo at 1 and 3 months, especially in patients with lower baseline iron levels, indicating improved energy efficiency linked to iron use.
Circulating antigen carbohydrate 125 (CA125) has emerged as a proxy of fluid overload in heart failure. This study aimed to evaluate the effect of dapagliflozin on short-term CA125 levels in patients with stable heart failure with reduced ejection fraction (HFrEF) and whether these changes mediated the effects on peak oxygen consumption (peakVO). This study is a post-hoc sub-analysis of a randomized, double-blinded clinical trial in which 90 stable patients with HFrEF were randomly assigned to receive either dapagliflozin or placebo to evaluate change in peakVO (NCT04197635).
View Article and Find Full Text PDFArticle Synopsis
- Conflicting evidence exists on how preoperative psychological evaluations affect weight outcomes in bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB).
- This study examined the role of psychiatric profiles, including anxiety and depression, on preoperative BMI and both short-term (1 year) and long-term (5 years) weight loss in patients who underwent RYGB.
- Findings revealed that high preoperative anxiety levels were linked to faster weight regain over time, suggesting the need for ongoing psychiatric support and customized management strategies to minimize weight regain post-surgery.