Publications by authors named "M Amagai"
Since nail psoriasis restricts the patient's daily activities, therapeutic intervention based on reliable and reproducible evaluation is critical. The Nail Psoriasis Severity Index (NAPSI) is a validated scoring tool, but its usefulness is limited by interobserver variability. This study aimed to develop a reliable and accurate NAPSI scoring tool using deep learning.
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- Researchers identified a new species of bacteria related to skin infections in patients with atopic dermatitis (AD) by analyzing lesions and conducting genome sequencing.
- The isolated bacteria produce a protein similar to staphylococcal enterotoxin Y (SEY), which activates T cells in a different way than other known superantigens, primarily through the T-cell receptor (TCR) Vα pathway.
- Immunological tests showed that this new protein, called SargEY, can stimulate T-cell proliferation and has the potential to worsen skin conditions in AD patients.
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- - The study investigates the effectiveness of trastuzumab and docetaxel chemotherapy for treating metastatic extramammary Paget's disease (EMPD), a rare cancer that shows similarities to breast cancer, particularly regarding HER2 expression.
- - Thirteen Japanese patients participated in this phase II trial, receiving the chemotherapy combination for up to two years, with a primary focus on measuring response rates and safety.
- - Results showed a high objective response rate of 76.9% after three cycles of treatment, with manageable side effects, suggesting that this combination therapy is a promising option for HER2-positive metastatic EMPD.
Background: Cognitive behavioral therapy for insomnia (CBT-I) is among the recommended non-pharmacological treatments for patients with insomnia. While there are multiple reports on the effects of CBT-I treatment, few studies evaluating the factors associated with the treatment response to CBT-I have been reported. The present study aimed to confirm the effects of CBT-I in patients with insomnia and to examine the clinico-demographic factors that can predict the outcomes of CBT-I in these patients.
View Article and Find Full Text PDFThe stratum corneum is the outermost skin layer with a vital role in skin barrier function. It is comprised of dead keratinocytes (corneocytes) and is known to maintain its thickness by shedding cells, although, the precise mechanisms that safeguard stratum corneum maturation and homeostasis remain unclear. Previous ex vivo studies have suggested a neutral-to-acidic pH gradient in the stratum corneum.
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