Publications by authors named "M Altun"
Cellular target engagement technologies enable quantification of intracellular drug binding; however, simultaneous assessment of drug-associated phenotypes has proven challenging. Here, we present cellular target engagement by accumulation of mutant as a platform that can concomitantly evaluate drug-target interactions and phenotypic responses using conditionally stabilized drug biosensors. We observe that drug-responsive proteotypes are prevalent among reported mutants of known drug targets.
View Article and Find Full Text PDFBackground: Sarcopenia is an age-related muscle disease that increases the risk of falls, disabilities, and death. It is associated with increased muscle protein degradation driven by molecular signalling pathways including Akt and FOXO1. This study aims to identify genes, gene interactions, and molecular pathways and processes associated with muscle aging and exercise in older adults that remained undiscovered until now leveraging on an artificial intelligence approach called artificial neural network inference (ANNi).
View Article and Find Full Text PDFArticle Synopsis
- Emergency department (ED) crowding significantly impacts patient care and public health, primarily due to access block, which refers to delays in admitting patients needing hospitalization.
- The NEDOCS score provides a way to objectively measure the severity of this overcrowding by analyzing various factors such as patient volume and waiting times, revealing that over 81% of the time, the ED was overcrowded.
- The study found that reducing access block through timely admissions could significantly decrease overcrowding and that factors like boarding times during off-peak hours also play a role in alleviating the issue.
Background/aim: Although high muscle strength worsens the sense of force, it is unknown whether there is a relationship between this deterioration and the underlying molecular mechanisms. This study examined the relationship between decreased force sense (FS) acuity and strength-related gene expressions.
Materials And Methods: Maximal voluntary isometric contraction (MVIC) and FS (50% MVIC) tests were performed on the knee joints of twenty-two subjects.