Preclinical study of vitamin D deficiency in the pathogenesis of metabolic syndrome in rats.

Objective: To explore the impact of vitamin D deficiency (VD-) in the pathogenesis of metabolic syndrome (MetS).

Materials And Methods: Models of (VD-) and (MetS) were induced in male Wister rats by dividing into four groups, group-I for the development of (VD-) by intraperitoneal injection of paricalcitol for 3 weeks, group II for (MetS) model by adding 10% fructose to their drinking water for 8 weeks, the group III for induction of combined (VD- + MetS) and group-IV as a control. Ultimately, the parameters of (VD-) and (MetS) were assessed at zero time and after 8 weeks.