Pharmacokinetic Simulation and Area under the Curve Estimation of Drugs Subject to Enterohepatic Circulation.

Enterohepatic circulation (EHC) is a complex process where drugs undergo secretion and reabsorption from the intestinal lumen multiple times, resulting in pharmacokinetic profiles with multiple peaks. The impact of EHC on area under the curve (AUC) has been a topic of extensive debate, questioning the suitability of conventional AUC estimation methods. Moreover, a universal model for accurately estimating AUC in EHC scenarios is lacking.

Thermal stress analysis by finite elements of a metal-ceramic dental bridge during the cooling phase of a glaze treatment.

In the present paper, a computational finite element analysis (FEA) was developed by using the COMSOL Multiphysics® software to evaluate the thermal accumulated stress on a 3-unit dental ceramic pressed over metal (POM) bridge, at different cooling rates during the glaze treatment. The cooling rates are related to the free opening of the furnace at 800 °C (extreme case) and the restricted opening when the restoration reaches 450 °C (slow case). The thermal expansion coefficients of the materials and the glass transition point of the ceramic were measured experimentally using a dilatometer test.

Fat Mass Index (FMI) as a Trustworthy Overweight and Obesity Marker in Mexican Pediatric Population.

Predictive formulas to estimate body composition in children have been explored for some time, to this date, the most accurate obesity diagnostic tool is to determine fat mass. The aim of this study is to establish cutoff points that allow for a precise interpretation of nutritional status using the Fat Mass Index (FMI) in a Mexican pediatric population. A literature review using PubMed and Cochrane databases was made, searching for research articles on childhood obesity that compared BMI, FM percentage, and FMI, as well as those proposing diagnostic cutoff points.

Smoothed Body Composition Percentiles Curves for Mexican Children Aged 6 to 12 Years.

Overweight children and childhood obesity are a public health problem in Mexico. Obesity is traditionally assessed using body mass index (BMI), but an excess of adiposity does not necessarily reflect a high BMI. Thus, body composition indexes are a better alternative.

Cadmium determination in natural water samples with an automatic multisyringe flow injection system coupled to a flow-through screen printed electrode.

Heavy metals, as cadmium, attract a rising attention in environmental studies due to their increasing release by human activities and acute toxicity. In situ analytical methods are needed to minimize current uncertainties caused by the transport and conservation of samples. Here, we present the completely automatic determination of Cd in natural waters using a newly developed screen printed electrode sensor (SPE), inserted in a homemade purpose-built flow cell coupled to a Multi-Syringe Flow Injection Analysis system (MSFIA).