A review on the effects of discharging conventionally treated livestock waste to the environmental resistome.

Globally, animal production has developed rapidly as a consequence of the ongoing population growth, to support food security. This has consequently led to an extensive use of antibiotics to promote growth and prevent diseases in animals. However, most antibiotics are not fully metabolized by these animals, leading to their excretion within urine and faeces, thus making these wastes a major reservoir of antibiotics residues, antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) in the environment.

In silico analysis reveals mir-98-5p as a potential inhibitor of tumor cell proliferation and metastasis in colorectal cancer by targeting the fzd3 receptor of the Wnt signaling pathway.

Background: Colorectal Cancer (CRC) is the third most common cancer type and the second leading cause of cancer-related deaths worldwide. However, the existing treatment, as well as prognosis strategies for CRC patients, need to be improved in order to increase the chance of survival. Targeted therapies of CRC, as opposed to ordinary therapies, target key biological features and pathways of cancerous cells hence minimizing the subsequent damage to normal cells.

Rare organ manifestations of sarcoidosis.

Purpose: We retrospectively analyzed the frequency and clinical characteristics of organs rarely involved with sarcoidosis in a cohort of 1158 sarcoidosis patients cared for over nearly 11 years in a university outpatient sarcoidosis clinic.

Methods: Data were analyzed from an institution-approved sarcoidosis clinical database containing demographic and clinical characteristics of sarcoidosis outpatients cared for between May 2011 and March 2021 at a university medical center sarcoidosis clinic. The diagnosis of sarcoidosis was established by standard international criteria.

Development of a novel rationally designed antibiotic to inhibit a nontraditional bacterial target.

The search for new nontraditional targets is a high priority in antibiotic design today. Bacterial membrane energetics based on sodium ion circulation offers potential alternative targets. The present work identifies the Na-translocating NADH:ubiquinone oxidoreductase (Na-NQR), a key respiratory enzyme in many microbial pathogens, as indispensible for the Chlamydia trachomatis infectious process.

Pancreatic tuberculous abscess diagnosed by endoscopic ultrasound-guided fine needle aspiration.

Endoscopic ultrasonography guided fine needle aspiration is a useful diagnostic aid in evaluation of cystic pancreatic mass. We report our patient with pancreatic tuberculous abscess who presented with pyrexia, and was found to have cystic pancreatic mass on CT scan. Pancreatic tuberculous abscess was diagnosed with the help of endoscopic ultrasound (EUS)-guided fine needle aspiration cytology (FNAC), thereby obviating the necessity for surgery.