Physiological equivalent temperature and hospitalized due to respiratory and cardiovascular diseases in Dezful, Iran.

Background: The Physiological Equivalent Temperature (PET) index providing a standardized reference point, PET enables non-experts to better understand and assess the physiological implications of varying environmental temperatures and thermal comfort levels across different settings. We aimed to evaluate the relationships between the PET Index and Hospitalized due to Respiratory Diseases (RD) and Cardiovascular Diseases (CVD) in Dezful city.

Method: Hospital admissions, climate variables and environmental pollution data (PM, PM) of Dezful city were collected from 2014 to 2019.

Advancements in machine learning and biomarker integration for prenatal Down syndrome screening.

The use of machine learning (ML) in biomarker analysis for predicting Down syndrome exemplifies an innovative strategy that enhances diagnostic accuracy and enables early detection. Recent studies demonstrate the effectiveness of ML algorithms in identifying genetic variations and expression patterns associated with Down syndrome by comparing genomic data from affected individuals and their typically developing peers. This review examines how ML and biomarker analysis improve prenatal screening for Down syndrome.

Multiple sclerosis and self-alienation: a study based on self and others representations.

Background: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. MS causes many changes in the lives of its patients, forcing them to renegotiate their lives. Part of these changes are related to patients' self- and others- mental representations.

Comparison of the effectiveness of self-care educational program using animation and role-playing on quality of life in adolescents with type 1 diabetes.

Background: Type 1 diabetes is a chronic disease and the number of Adolescents diagnosed with it, is at an increase. Self-care education can reduce the complications of this disease. Therefore, this research was conducted to determine and compare the effectiveness of self-care educational programs, using animation and role-playing on quality of life in Adolescents with type 1 diabetes.

Structural and functional properties of the N- and C-terminal segments of the P4-ATPase phospholipid flippase ATP8A2.

ATP8A2 is a P4-ATPase that actively flips phosphatidylserine and to a lesser extent phosphatidylethanolamine across cell membranes to generate and maintain transmembrane phospholipid asymmetry. The importance of this flippase is evident in the finding that loss-of-function mutations in ATP8A2 are known to cause the neurodevelopmental disease known as cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 4 (CAMRQ4) in humans and related neurodegenerative disorders in mice. Although significant progress has been made in understanding mechanisms underlying phospholipid binding and transport across the membrane domain, little is known about the structural and functional properties of the cytosolic N- and C-terminal segments of this flippase.