Publications by authors named "M Alegre"
Introduction: Our objective is to study the relationship between armed conflict injuries and pain and the treatments that have been applied to Ukrainian injured soldiers in our hospital.
Methods: We performed an observational study of a sample of 91 injured soldiers. The metrics we selected for the study included time from injury, length of stay, diagnosis, treatment, type and intensity of pain and questionnaires about pain and quality of life for the group of amputees.
The microbiota composition is known to influence the kinetics of graft rejection, but many questions remain as to whether/how microbiota-derived metabolites affect graft outcome. We investigated the effects of the short-chain fatty acid butyrate, a product of dietary fiber fermentation. Sustained intragastric administration of a micelle-based formulation of butyrate (butyrate micelle [ButM]) that releases its cargo in the lower gastrointestinal tract elevated cecal butyrate content and significantly prolonged minor-mismatched and major-mismatched skin allograft survival in mice.
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- Long-term tolerance without immunosuppressive drugs is a key aim in transplantation, which has yet to be achieved.
- New research highlights the role of gut microbiota in immune regulation, suggesting it could lead to innovative treatments.
- Tryptophan (Trp) and its metabolites are being explored for their effects on immune responses and their potential to enhance transplant survival.
Article Synopsis
- This study investigates the effectiveness of a "wait-and-scan" approach using MRI for managing patients with small to medium-sized vestibular schwannomas (VS), aiming to assess patient adherence to follow-up.
- Over six years, 270 patients were tracked, revealing that 27% were completely lost to follow-up before receiving treatment, while another 22% missed scheduled MRI follow-ups.
- The research identified key factors for loss to follow-up, including living out of state and having smaller tumor sizes, indicating that distance and tumor characteristics significantly impact patient adherence to recommended imaging surveillance.
Successful allograft specific tolerance induction would eliminate the need for daily immunosuppression and improve post-transplant quality of life. Adoptive cell therapy with regulatory T cells expressing donor-specific Chimeric Antigen Receptors (CAR-Tregs) is a promising strategy, but as monotherapy, cannot prolong the survival with allografts with multiple MHC mismatches. Using an HLA-A2-transgenic haplo-mismatched heart transplantation model in immunocompetent C57Bl/6 recipients, we show that HLA-A2-specific (A2) CAR Tregs was able to synergize with low dose of anti-CD154 to enhance graft survival.
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