Publications by authors named "M Albani"
Article Synopsis
- Understanding posture is crucial for how mammals move, and dysregulation of certain brain chemicals, specifically dopamine and noradrenaline, can lead to motor problems in diseases like spinal muscular atrophy (SMA).
- Research using a mouse model of SMA revealed that the loss of synapses in the spinal neurons, caused by non-cell autonomous mechanisms, contributes to motor dysfunction and postural issues.
- Restoring a specific protein (survival motor neuron) in either catecholaminergic or serotonergic neurons can improve movement, but significant postural issues only improve with restoration in both neuron types or treatment with l-dopa, highlighting new potential treatment strategies.
(1) Autophagy plays a significant role in development and cell proliferation. This process is mainly accomplished by the LC3 protein, which, after maturation, builds the nascent autophagosomes. The inhibition of LC3 maturation results in the interference of autophagy activation.
View Article and Find Full Text PDFArctic alpine species experience extended periods of cold and unpredictable conditions during flowering. Thus, often, alpine plants use both sexual and asexual means of reproduction to maximize fitness and ensure reproductive success. We used the arctic alpine perennial to explore the role of prolonged cold exposure on adventitious rooting.
View Article and Find Full Text PDFIntroduction: Proprotein convertase subtilisin/kexin 9 (PCSK9) plays a crucial role in breaking down the hepatic low-density lipoprotein receptor (LDLR), thereby influencing the levels of circulating low-density lipoprotein cholesterol (LDL-C). Consequently, inhibiting PCSK9 through suitable ligands has been established as a validated therapeutic strategy for combating hypercholesterolemia and cardiovascular diseases.
Area Covered: Patent literature claiming novel compounds inhibiting PCSK9 disclosed from 2018 to June 2023 available in the espacenet database, which contains more than 150 million patent documents from over 100 patent-granting authorities worldwide.
Since the beginning of recorded history, the human brain has been one of the most intriguing structures for scientists and engineers. Over the centuries, newer technologies have been developed based on principles that seek to mimic their functioning, but the creation of a machine that can think and behave like a human remains an unattainable fantasy. This idea is now known as "artificial intelligence".
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