Publications by authors named "M Alaee"
Article Synopsis
- Metformin, a commonly prescribed diabetes medication, is often detected in wastewater and surface waters due to its stability and poor breakdown, potentially harming aquatic ecosystems.
- An 8-week experiment in a freshwater lake tested the impact of metformin at concentrations of 0, 5, and 50 μg/L on various aquatic organisms, including microbes and zooplankton.
- Results showed that metformin remained stable in water, with no significant adverse effects on aquatic communities or organisms, suggesting limited environmental impact despite its high concentration in wastewater.
Background: Silymarin is a flavonolignan that has various medicinal properties such as liver protection, antioxidant, anti-inflammatory, anti-cancer and heart protection activities. The aim of this study was to investigate the effect of silymarin on the expression level of , matrix metalloproteinase(), and their tissue inhibitors () in liver cancer HepG2 cell line.
Methods: An experimental study was conducted on the human HepG2 cells prepared from Pasteur Institute, Tehran, Iran.
Article Synopsis
- Metformin, a common treatment for Type-2 diabetes, is found in surface waters worldwide, raising concerns about its impact on fish health, especially adult males.
- A study was conducted in a natural lake to assess the effects of metformin on wild fathead minnows, exposing them to low and high concentrations while monitoring various health metrics over 8 weeks.
- Results showed that metformin exposure led to significant weight loss, altered body composition, and reproductive issues in male fish, indicating potential risks to wild fish populations from this environmental contaminant.
The high environmental concentrations, persistence, and toxicity of synthetic musk compounds (SMCs) necessitate a better grasp of their fate in wastewater treatment plants (WWTPs). To investigate the importance of WWTPs as pathways of SMCs to the environment, air and wastewater samples were collected at four WWTPs in Ontario, Canada. Polycyclic musks (PCMs) were present at higher concentrations than nitro musks (NMs) and macrocyclic musks (MCMs).
View Article and Find Full Text PDFHydroalcoholic extract of has a significant therapeutic effect on thioacetamide-induced liver cirrhosis in rats.
Horm Mol Biol Clin Investig
December 2023
Objectives: Liver cirrhosis is one of the most important causes of death from liver diseases. Nowadays, the use of herbal medicines has increased due to its availability, less side effects and cheapness for the treatment of liver diseases. The present study was conducted to examine therapeutic effects of hydroalcoholic extract of () on thioacetamide-induced liver cirrhosis in rats through evaluate its effects on oxidative stress markers and the expression of metalloproteinase 1 (TIMP 1), toll-like receptor-4 (TLR-4), and Mitofusin (MFN2) genes.
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