Publications by authors named "M Al-Hussaini"
The shift toward a histo-molecular approach in World Health Organization classification of central nervous system tumors (WHO CNS5) emphasizes the critical role of molecular testing, such as next-generation sequencing (NGS) and DNA methylation profiling, for accurate diagnosis. However, implementing these advanced techniques is particularly challenging in resource-constrained countries. To address this, the Asian Oceanian Society of Neuropathology committee for Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions (AOSNP-ADAPTR) was initiated to help pathologists in resource-limited regions to implement WHO CNS5 diagnoses using simpler diagnostic tools, mainly immunohistochemistry.
View Article and Find Full Text PDFIntroduction: The global shortage of healthcare professionals is a critical concern, with an estimated deficit of 18 million workers by 2030, particularly in low- and middle-income countries. Oman faces challenges with its doctor-to-population ratio falling below the global average. This study examines the factors influencing residency program choices among Omani medical students and interns, with a specific focus on internal medicine.
View Article and Find Full Text PDFArticle Synopsis
- Adult medulloblastoma is uncommon, and treatment insights are mostly drawn from studies of pediatric cases; this study analyzed adult cases treated at King Hussein Cancer Center to understand clinical features and outcomes.
- The study included 53 patients aged 18 and older, with comprehensive assessments of disease characteristics and treatment responses over a median follow-up of 70 months, noting that 37.7% of patients died during this period.
- The findings highlighted significant correlations between patient outcomes and factors such as the extent of surgery and risk status, while molecular subgrouping did not predict survival outcomes, indicating a need for more aggressive treatment in high-risk patients.
Introduction: Most pediatric low-grade-gliomas (LGG) and some high-grade-gliomas (HGG) have alterations in the RAS/MAPK pathway. Promising high tumor response rates were achieved using BRAF/MEK inhibitors, however data on their use in low-middle-income-countries (LMICs) are limited.
Methods: We retrospectively reviewed our Jordanian experience of using compassionate BRAF/MEK inhibitors in treating children with gliomas.
Article Synopsis
- Juvenile xanthogranuloma (JXG) is a type of skin tumor mostly found in children, but some cases occur in other parts of the body, and their genetic causes are not fully understood.* -
- A study analyzed 16 children and 5 adults with extracutaneous JXG using advanced sequencing, finding that numerous genetic alterations, especially related to kinase fusions, were present in most children.* -
- The findings indicate that while surgery is common for treatment, some cases can regress on their own, and specific genetic alterations could help inform better treatment options in the future.*